Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798936..799614 Replicon chromosome
Accession NZ_CP025003
Organism Dickeya fangzhongdai strain DSM 101947

Toxin (Protein)


Gene name cptA Uniprot ID A0A2K8QJH4
Locus tag CVE23_RS03815 Protein ID WP_049854564.1
Coordinates 799183..799614 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A2K8QSU7
Locus tag CVE23_RS03810 Protein ID WP_023637600.1
Coordinates 798936..799202 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVE23_RS03790 795365..796015 + 651 WP_038917839.1 LysE family translocator -
CVE23_RS03795 796086..796694 - 609 WP_100848933.1 HD domain-containing protein -
CVE23_RS03800 796905..797555 + 651 WP_038917842.1 hemolysin III family protein -
CVE23_RS03805 797645..798625 - 981 WP_100848934.1 tRNA-modifying protein YgfZ -
CVE23_RS03810 798936..799202 + 267 WP_023637600.1 FAD assembly factor SdhE Antitoxin
CVE23_RS03815 799183..799614 + 432 WP_049854564.1 protein YgfX Toxin
CVE23_RS03820 799714..800232 - 519 WP_038662307.1 flavodoxin FldB -
CVE23_RS03825 800361..801686 - 1326 WP_038662304.1 MHS family MFS transporter -
CVE23_RS03830 801949..802848 + 900 WP_038917846.1 site-specific tyrosine recombinase XerD -
CVE23_RS03835 802937..803653 + 717 WP_038917847.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 16793.54 Da        Isoelectric Point: 11.7737

>T89455 WP_049854564.1 NZ_CP025003:799183-799614 [Dickeya fangzhongdai]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLLQHPLQGTESSRHH

Download         Length: 432 bp

>T89455 NZ_CP025003:799183-799614 [Dickeya fangzhongdai]
GTGGCCCAGTGGCAATGTGATTTGCGTGTATCCTGGCGCATGCAGTTGTTTTCTCTGCTGACGCACGGGTTCCTGGTGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTATGCGCCGCTGTGGCTGGGGTTGGTGACGCTGGTGGTGTTCGGTTTCG
TGCGCAGTCAGCGCATCATCAAGTCGCGTCAGGGGGAAATTTCCCTGCATGGGGAAAACCAACTGCACTGGCAACAGCGT
GACTGGCAGATAGCCCGGCGACCGTGGGTGATGCGCAACGGCGTGTTGCTGTCGTTGCGGGCGACGACCGGCAAAGGGCA
TCAGCGCTTGTGGCTGGCGTCAGACAGTATGGGCAATGAAGAGTGGCGGCTGTTGCGCCAACTGTTGCTGCAGCATCCGC
TGCAGGGCACGGAATCCTCCCGCCATCATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.03 Da        Isoelectric Point: 5.5535

>AT89455 WP_023637600.1 NZ_CP025003:798936-799202 [Dickeya fangzhongdai]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT89455 NZ_CP025003:798936-799202 [Dickeya fangzhongdai]
ATGGACATCAATAACAAATCACGCATTCACTGGGCGTGCAGACGCGGAATGCGTGAACTGGATATTTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTGAGCGACGACGACAAGCAGCATTTCATCCGTCTGTTGCAGTGCGACGATCCCGACT
TGTTCAACTGGCTGATGAACCACGGCGAGCCGGTGGATCCGGAGCTGAAGCGCATGGTTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8QJH4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QSU7

References