Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1503989..1505556 Replicon chromosome
Accession NZ_CP025000
Organism Idiomarina sp. X4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CWC33_RS07200 Protein ID WP_100691394.1
Coordinates 1503989..1505299 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CWC33_RS07205 Protein ID WP_100692300.1
Coordinates 1505299..1505556 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC33_RS07170 1500432..1501160 - 729 WP_100691391.1 hypothetical protein -
CWC33_RS07175 1501157..1502005 - 849 WP_100692299.1 phosphatidylserine decarboxylase -
CWC33_RS07180 1502050..1503093 - 1044 WP_100691392.1 small ribosomal subunit biogenesis GTPase RsgA -
CWC33_RS07185 1503163..1503714 + 552 WP_100691393.1 oligoribonuclease -
CWC33_RS07200 1503989..1505299 - 1311 WP_100691394.1 type II toxin-antitoxin system HipA family toxin Toxin
CWC33_RS07205 1505299..1505556 - 258 WP_100692300.1 helix-turn-helix domain-containing protein Antitoxin
CWC33_RS07210 1505687..1506832 - 1146 WP_100691395.1 dicarboxylate/amino acid:cation symporter -
CWC33_RS07215 1506878..1507795 - 918 WP_100691396.1 histone deacetylase family protein -
CWC33_RS07220 1507799..1509640 - 1842 WP_100691397.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-396)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48885.23 Da        Isoelectric Point: 8.9348

>T89447 WP_100691394.1 NZ_CP025000:c1505299-1503989 [Idiomarina sp. X4]
MDKLDIYMNGLLVGELHRSHSGAHRFNYSINWLNTPGARPISLSMPLTRSAYEGAEVINFFDNLLPDNQEVRDRIVARYR
ADSKQPFDLLKAVGRDTVGALQFYPQGEQPGNIKTINYKPLNASELEKVLLGYQSKAPLGMVNELNDFRISIAGAQEKTA
LLKIEDKWCVPEGATPTSHIIKLPIGKIQGADHTIDLSDSVENELLCLEIAREFGFDVPACEIVNTGKVKALAVERFDRK
YSSDKSWLMRLPQEDYCQVLSCPSARKYEPDGGPSIAQIMKHLQSSSNAHKDRQTFMAAQVLFFLLGATDGHAKNFSVYI
EPGGSFKLTPLYDILSAYPAVGGQGLHLRDLKLAMTLKGSKGRKSKLFQIYGRHFISSAKEAQYSLKEMQDVLKVMHEST
DNVIEKVSKRLPKHFPMKVAEPIFEGLRLRKERLIS

Download         Length: 1311 bp

>T89447 NZ_CP025000:c1505299-1503989 [Idiomarina sp. X4]
ATGGATAAACTCGATATTTATATGAACGGGCTACTGGTCGGTGAGCTGCACCGTAGTCACTCTGGCGCCCACCGTTTTAA
CTACAGTATCAACTGGCTCAATACACCGGGCGCCCGCCCAATTTCGTTATCAATGCCTCTAACAAGAAGCGCCTACGAAG
GTGCTGAAGTCATCAACTTTTTCGATAACCTTCTGCCCGATAACCAGGAAGTTCGAGACCGGATTGTTGCGCGCTATCGA
GCCGACTCGAAACAACCTTTTGATCTTCTCAAAGCAGTAGGTCGAGACACAGTAGGCGCTTTACAGTTTTACCCCCAAGG
GGAACAACCTGGCAATATAAAGACAATCAACTACAAGCCTCTCAATGCAAGCGAGTTAGAAAAGGTTCTTCTAGGCTATC
AGTCAAAGGCACCGCTTGGCATGGTGAATGAGCTCAATGACTTTCGTATATCTATAGCTGGTGCACAAGAGAAAACTGCG
TTACTTAAAATAGAAGATAAATGGTGTGTTCCCGAAGGAGCTACACCGACAAGCCACATCATCAAGCTCCCTATCGGCAA
GATCCAAGGAGCAGACCATACTATCGACTTATCCGACAGCGTTGAAAATGAGCTGCTGTGTCTGGAAATCGCCAGGGAAT
TTGGGTTCGACGTGCCAGCTTGTGAAATTGTAAATACAGGTAAAGTAAAGGCTCTGGCCGTAGAGCGCTTTGATCGTAAA
TATTCCAGCGATAAATCCTGGCTCATGCGCCTGCCACAAGAGGACTACTGTCAGGTACTTAGTTGCCCCTCCGCTCGCAA
GTACGAACCTGACGGCGGTCCATCTATAGCGCAAATTATGAAACATCTACAAAGCTCTTCTAATGCCCATAAAGACAGAC
AAACCTTTATGGCTGCGCAGGTGCTATTTTTTCTGCTAGGCGCAACCGACGGACATGCTAAAAACTTTTCTGTGTATATC
GAGCCAGGCGGTTCTTTCAAGTTAACTCCGCTTTACGACATTCTTTCTGCGTACCCAGCAGTCGGAGGTCAAGGGCTTCA
TTTAAGAGACTTAAAACTCGCTATGACACTTAAAGGCTCAAAAGGTCGAAAATCAAAGCTTTTTCAGATCTACGGGCGTC
ACTTCATCAGTTCAGCAAAGGAAGCGCAGTACAGCCTAAAAGAGATGCAGGATGTCCTTAAGGTAATGCATGAAAGCACA
GATAACGTTATTGAAAAAGTTAGTAAGCGCTTACCCAAGCACTTTCCAATGAAAGTTGCAGAGCCTATTTTTGAAGGTCT
TCGTCTTCGAAAAGAGAGACTTATTAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9621.81 Da        Isoelectric Point: 6.7260

>AT89447 WP_100692300.1 NZ_CP025000:c1505556-1505299 [Idiomarina sp. X4]
MKITSPHALAAHLKDERKRQNLSQTKVAEFVGLRQGTVSSFELSPEKSQIDTLFRLLSALGLELNIKSKEDAQGNTTEHS
WNEEW

Download         Length: 258 bp

>AT89447 NZ_CP025000:c1505556-1505299 [Idiomarina sp. X4]
ATGAAAATTACAAGCCCCCACGCTTTAGCTGCCCATTTGAAAGATGAAAGGAAACGCCAAAATTTAAGTCAGACAAAAGT
TGCTGAATTTGTTGGTTTAAGGCAAGGCACTGTCTCAAGCTTTGAACTTTCTCCTGAGAAAAGCCAAATAGATACGTTAT
TTCGGCTTCTATCAGCGCTTGGACTAGAGTTAAACATTAAGAGCAAGGAAGACGCTCAGGGAAACACCACTGAACACTCA
TGGAATGAGGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References