Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 657151..658802 Replicon chromosome
Accession NZ_CP025000
Organism Idiomarina sp. X4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CWC33_RS03135 Protein ID WP_100690747.1
Coordinates 657456..658802 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CWC33_RS03130 Protein ID WP_100690746.1
Coordinates 657151..657459 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC33_RS03110 652995..654812 - 1818 WP_100690743.1 DUF1302 domain-containing protein -
CWC33_RS03115 655005..655934 - 930 WP_100690744.1 FAD-binding protein -
CWC33_RS03120 655931..656680 - 750 WP_088768825.1 electron transfer flavoprotein subunit beta/FixA family protein -
CWC33_RS03125 656806..657177 + 372 WP_100690745.1 SufE family protein -
CWC33_RS03130 657151..657459 - 309 WP_100690746.1 helix-turn-helix domain-containing protein Antitoxin
CWC33_RS03135 657456..658802 - 1347 WP_100690747.1 type II toxin-antitoxin system HipA family toxin Toxin
CWC33_RS03140 659013..659795 - 783 WP_100690748.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
CWC33_RS03145 659788..660207 - 420 WP_088768828.1 PAS domain-containing protein -
CWC33_RS03150 660204..661226 - 1023 WP_100690749.1 response regulator -
CWC33_RS03155 661420..662271 - 852 WP_100690750.1 thymidylate synthase -
CWC33_RS03160 662454..663251 - 798 WP_100690751.1 prolipoprotein diacylglyceryl transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-363)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-86)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50758.14 Da        Isoelectric Point: 4.5394

>T89443 WP_100690747.1 NZ_CP025000:c658802-657456 [Idiomarina sp. X4]
MNSLTIQAYLQSQWQDIAMLTFTERTGQNEPDVQVQYKTGYAIEHLEQDDHHAVSLNHPVQLYFDDDDQPGWLRFLDDII
PSGAARRFWVDQLEISNLPLSEQNLVLLEKAAIAPVGHLRIKEAVENQNETIDPPQFSVSDVVERNASFLEYAHQRGAIA
GGATGAGGEAPKLLLRCNNNDEVWIDTFQDGTNIQDAFYLVKFPRGQRKQIDCDILRAEYHFYCELEEMGVSTITTEQMR
LEEGENFPSLWLPRFDVDVVNGVVARKAMESVYSILKRAPGVRLRHADVIRNLVRKIENSYTVKEQGAPFNVEAFVTEWV
RRDLLNIAFGNSDNHGRNTAFFRDEGGIKLTPIYDFAPMRADPEGVPRSTVWGEPMESGGEYNFGAICEELSDLIKPEQL
LSDLNTTAEQFIGLESRLRERGVPDSIMTMPKVGLANIPEKLKRWGLL

Download         Length: 1347 bp

>T89443 NZ_CP025000:c658802-657456 [Idiomarina sp. X4]
ATGAATAGTCTGACGATACAGGCTTATCTGCAAAGCCAATGGCAGGACATAGCCATGTTAACTTTTACTGAACGAACCGG
ACAGAATGAGCCCGACGTACAAGTGCAGTATAAAACGGGCTACGCTATTGAACACCTGGAGCAGGATGATCACCATGCTG
TTTCCTTAAACCATCCCGTTCAGCTTTACTTTGATGATGACGATCAACCCGGTTGGCTTCGCTTTCTTGATGATATTATC
CCAAGCGGCGCGGCGCGAAGGTTTTGGGTAGATCAGCTTGAAATATCGAACTTGCCACTAAGCGAACAAAATTTGGTTTT
ATTAGAAAAAGCCGCAATTGCACCTGTTGGGCATTTGAGAATAAAAGAAGCTGTCGAAAACCAGAACGAAACTATAGACC
CTCCTCAGTTTAGTGTCAGCGATGTTGTAGAAAGAAACGCGAGTTTTCTTGAGTATGCTCATCAGCGAGGAGCCATTGCC
GGAGGAGCAACCGGTGCGGGTGGCGAGGCGCCAAAATTATTACTGCGATGCAACAATAATGACGAGGTTTGGATAGATAC
CTTTCAAGACGGAACTAATATTCAGGATGCATTTTATCTGGTGAAGTTTCCTCGGGGTCAACGAAAGCAAATTGACTGCG
ATATCTTGCGCGCGGAATATCACTTTTATTGCGAGCTAGAGGAAATGGGAGTTAGCACCATAACAACCGAACAGATGAGG
CTTGAAGAAGGTGAAAACTTTCCGTCGCTTTGGCTTCCGCGCTTCGATGTTGATGTTGTTAATGGCGTGGTTGCTCGCAA
GGCAATGGAGTCTGTTTACTCAATATTAAAGCGAGCGCCCGGTGTGCGCCTTCGTCATGCTGATGTAATACGTAATTTAG
TCCGCAAAATTGAAAACTCTTATACGGTTAAAGAACAAGGCGCTCCCTTTAATGTAGAGGCGTTCGTAACCGAATGGGTA
CGGAGGGATTTATTGAATATTGCTTTTGGTAACTCGGATAATCACGGTCGCAATACGGCATTTTTCAGAGATGAAGGCGG
CATAAAGCTCACTCCAATTTATGATTTTGCGCCGATGCGAGCTGACCCCGAAGGAGTGCCAAGATCAACTGTTTGGGGAG
AGCCAATGGAAAGTGGCGGCGAATATAACTTTGGAGCCATCTGCGAGGAGCTTTCTGACTTAATCAAACCTGAACAATTG
CTCAGTGACCTGAATACAACGGCTGAGCAATTTATTGGCTTGGAAAGCAGATTAAGGGAGCGGGGCGTTCCAGACAGTAT
TATGACCATGCCCAAAGTCGGGCTGGCTAATATTCCAGAAAAACTGAAACGCTGGGGGCTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11507.18 Da        Isoelectric Point: 10.8242

>AT89443 WP_100690746.1 NZ_CP025000:c657459-657151 [Idiomarina sp. X4]
MSKSNQLSGEEREALIERIALQLLQGDISQGQALQEFRKKITGLNQSDYAKLTRTSRKTISEVENDLGNYSSDIINRLFK
PFGLKVGLVPASARLKRRTLRT

Download         Length: 309 bp

>AT89443 NZ_CP025000:c657459-657151 [Idiomarina sp. X4]
ATGAGTAAGAGTAACCAGCTTAGCGGTGAAGAGCGAGAAGCTCTTATTGAACGTATTGCGCTACAACTATTACAGGGTGA
CATAAGCCAGGGACAAGCGTTGCAGGAGTTCAGGAAAAAAATTACTGGGCTGAATCAAAGCGATTATGCCAAGCTCACAA
GAACTTCCCGAAAGACCATTTCAGAAGTTGAAAATGATCTAGGCAATTATTCTAGCGACATAATTAATCGACTGTTTAAG
CCCTTTGGGTTAAAAGTCGGCCTGGTTCCGGCATCCGCTCGGTTAAAGCGCCGAACATTGCGTACGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References