Detailed information of TA system TA089437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1608408..1608922
• Replicon: chromosome
• Accession: NZ_CP024998
• Organism: Staphylococcus aureus strain 55-99-44

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: CU118_RS08295
• Protein ID: WP_054190442.1
• Coordinates: 1608408..1608617 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: CU118_RS08300
• Protein ID: WP_000138934.1
• Coordinates: 1608629..1608922 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CU118_RS08275	1603916..1605274	-	1359	WP_054190439.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
CU118_RS08280	1605289..1606359	-	1071	WP_054190440.1	D-alanine--D-alanine ligase	-
CU118_RS08285	1606677..1607879	+	1203	WP_054190441.1	rod shape-determining protein RodA	-
CU118_RS08290	1608143..1608280	-	138	WP_000828354.1	hypothetical protein	-
CU118_RS08295	1608408..1608617	-	210	WP_054190442.1	heavy-metal-associated domain-containing protein	Toxin
CU118_RS08300	1608629..1608922	-	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
CU118_RS08305	1609092..1610576	+	1485	WP_054190443.1	cardiolipin synthase	-
CU118_RS08310	1610604..1611251	+	648	WP_001187616.1	HD domain-containing protein	-
CU118_RS08325	1611831..1612703	-	873	WP_000725800.1	membrane protein insertase YidC	-
CU118_RS08330	1612789..1613430	-	642	WP_054190444.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7830.77 Da
• Isoelectric Point: 4.1008

>T89437 WP_054190442.1 NZ_CP024998:c1608617-1608408 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISSMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKILF

Nucleotide

• Length: 210 bp

>T89437 NZ_CP024998:c1608617-1608408 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAG
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTTTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT89437 WP_000138934.1 NZ_CP024998:c1608922-1608629 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT89437 NZ_CP024998:c1608922-1608629 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATCAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1GBN9