Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1009209..1009997 Replicon chromosome
Accession NZ_CP024998
Organism Staphylococcus aureus strain 55-99-44

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag CU118_RS04980 Protein ID WP_000525004.1
Coordinates 1009536..1009997 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag CU118_RS04975 Protein ID WP_000333630.1
Coordinates 1009209..1009523 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CU118_RS04915 1004351..1005517 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
CU118_RS04920 1005514..1005876 - 363 WP_000985984.1 hypothetical protein -
CU118_RS04925 1005891..1006214 - 324 WP_000175001.1 hypothetical protein -
CU118_RS04930 1006293..1006454 - 162 WP_001285954.1 DUF1270 domain-containing protein -
CU118_RS04935 1006467..1006730 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
CU118_RS04940 1006755..1006970 - 216 WP_001097552.1 hypothetical protein -
CU118_RS04945 1007025..1007390 + 366 WP_001128433.1 hypothetical protein -
CU118_RS04950 1007359..1007604 - 246 WP_001025401.1 DUF2829 domain-containing protein -
CU118_RS04955 1007660..1007869 + 210 WP_000642492.1 hypothetical protein -
CU118_RS04960 1007859..1008002 - 144 WP_000939498.1 hypothetical protein -
CU118_RS04965 1008031..1008807 - 777 WP_001148544.1 Rha family transcriptional regulator -
CU118_RS04970 1008821..1009057 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
CU118_RS04975 1009209..1009523 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
CU118_RS04980 1009536..1009997 + 462 WP_000525004.1 hypothetical protein Toxin
CU118_RS04985 1010015..1010449 + 435 WP_000755718.1 hypothetical protein -
CU118_RS04990 1010478..1010873 + 396 WP_000449655.1 hypothetical protein -
CU118_RS04995 1010963..1011109 + 147 WP_001795334.1 hypothetical protein -
CU118_RS05000 1011106..1011720 - 615 WP_000191466.1 hypothetical protein -
CU118_RS05005 1011846..1013051 + 1206 WP_100793815.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 964440..1030690 66250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T89430 WP_000525004.1 NZ_CP024998:1009536-1009997 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T89430 NZ_CP024998:1009536-1009997 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT89430 WP_000333630.1 NZ_CP024998:1009209-1009523 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT89430 NZ_CP024998:1009209-1009523 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References