Detailed information of TA system TA089425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 308331..308808
• Replicon: chromosome
• Accession: NZ_CP024998
• Organism: Staphylococcus aureus strain 55-99-44

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: CU118_RS01525
• Protein ID: WP_000052076.1
• Coordinates: 308331..308519 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: CU118_RS01530
• Protein ID: WP_001059689.1
• Coordinates: 308548..308808 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CU118_RS01495	304281..304838	+	558	WP_054189291.1	hypothetical protein	-
CU118_RS01500	305180..305866	+	687	WP_054189292.1	thermonuclease family protein	-
CU118_RS01505	306223..306423	+	201	WP_001059082.1	cold-shock protein	-
CU118_RS01510	306921..307139	-	219	WP_054189293.1	hypothetical protein	-
CU118_RS01515	307201..307485	-	285	WP_054189294.1	hypothetical protein	-
CU118_RS01520	307573..308142	-	570	WP_054189295.1	hypothetical protein	-
CU118_RS01525	308331..308519	-	189	WP_000052076.1	hypothetical protein	Toxin
CU118_RS01530	308548..308808	-	261	WP_001059689.1	hypothetical protein	Antitoxin
CU118_RS01535	309149..309352	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
CU118_RS01540	309349..309585	-	237	WP_000368687.1	hypothetical protein	-
CU118_RS01545	309809..310390	+	582	WP_054189296.1	phosphoglycerate mutase family protein	-
CU118_RS01550	310463..311080	-	618	WP_054189297.1	LysE/ArgO family amino acid transporter	-
CU118_RS01555	311236..311730	-	495	WP_054189298.1	GNAT family N-acetyltransferase	-
CU118_RS01560	312129..312551	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
CU118_RS01565	312699..313415	+	717	WP_100793799.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T89425 WP_000052076.1 NZ_CP024998:c308519-308331 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T89425 NZ_CP024998:c308519-308331 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10009.20 Da
• Isoelectric Point: 4.4986

>AT89425 WP_001059689.1 NZ_CP024998:c308808-308548 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYRFIG

Nucleotide

• Length: 261 bp

>AT89425 NZ_CP024998:c308808-308548 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACAACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATTACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCGATT
TTTTATAGGTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18