Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3834943..3835586 Replicon chromosome
Accession NZ_CP024985
Organism Streptomyces lavendulae subsp. lavendulae strain CCM 3239

Toxin (Protein)


Gene name vapC Uniprot ID A0A2K8PEP1
Locus tag SLAV_RS16515 Protein ID WP_030236472.1
Coordinates 3834943..3835359 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2K8PGB5
Locus tag SLAV_RS16520 Protein ID WP_030236475.1
Coordinates 3835356..3835586 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLAV_RS16490 3830556..3831428 - 873 WP_030236463.1 trypsin-like serine protease -
SLAV_RS16500 3831944..3833182 - 1239 WP_030236466.1 glycosyltransferase -
SLAV_RS16510 3833844..3834926 + 1083 WP_030236469.1 alpha/beta hydrolase -
SLAV_RS16515 3834943..3835359 - 417 WP_030236472.1 PIN domain nuclease Toxin
SLAV_RS16520 3835356..3835586 - 231 WP_030236475.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SLAV_RS16525 3835693..3836913 - 1221 WP_030236479.1 amidohydrolase -
SLAV_RS16530 3837069..3840146 + 3078 WP_030236481.1 tetratricopeptide repeat protein -
SLAV_RS16535 3840343..3840543 + 201 WP_030236484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(17-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14990.12 Da        Isoelectric Point: 6.0794

>T89418 WP_030236472.1 NZ_CP024985:c3835359-3834943 [Streptomyces lavendulae subsp. lavendulae]
MTRHFLIDKSALARYPKPAVRAVVNPLHTAGVLAVCGAVELEVLYSARSKSDADRVRAGLGAFAWLSTPDEAWDRALEVQ
EQLIVAGNWKAVSLPDLIIAATAERHEATVLHYDGDYDMIAKVTGQPTRWVVPPGTAD

Download         Length: 417 bp

>T89418 NZ_CP024985:c3835359-3834943 [Streptomyces lavendulae subsp. lavendulae]
ATGACCAGGCACTTCCTGATCGACAAGTCAGCCCTCGCGCGCTATCCCAAGCCGGCCGTGCGCGCCGTCGTCAATCCGCT
GCACACGGCAGGTGTACTCGCCGTGTGCGGCGCGGTGGAGCTGGAGGTGCTCTACAGCGCCCGCTCCAAGTCGGACGCCG
ACCGGGTCCGCGCGGGGCTGGGGGCCTTCGCGTGGCTCTCGACCCCGGACGAGGCGTGGGACCGGGCCCTGGAGGTCCAG
GAGCAGCTCATCGTGGCGGGCAACTGGAAAGCGGTGTCCCTTCCGGACCTGATCATCGCGGCGACCGCGGAGCGCCACGA
GGCGACCGTGCTGCACTACGACGGCGACTACGACATGATCGCCAAGGTCACGGGCCAGCCGACGCGCTGGGTCGTACCCC
CGGGCACGGCGGACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8129.20 Da        Isoelectric Point: 4.5535

>AT89418 WP_030236475.1 NZ_CP024985:c3835586-3835356 [Streptomyces lavendulae subsp. lavendulae]
MARTVIDVDDALLAEAAELFGTKTKVATVNAALRDAVNRRKREEFLNWLAEGGLPDLTGPVELLAAEGGHVQDRAA

Download         Length: 231 bp

>AT89418 NZ_CP024985:c3835586-3835356 [Streptomyces lavendulae subsp. lavendulae]
ATGGCCAGAACCGTGATCGACGTGGACGACGCCCTGCTGGCGGAGGCCGCCGAGCTCTTCGGAACGAAGACGAAGGTCGC
CACCGTCAACGCGGCCCTTCGGGACGCCGTCAACCGGCGCAAGAGGGAAGAGTTCCTGAACTGGCTCGCCGAGGGTGGAC
TGCCGGACCTGACGGGCCCGGTCGAGCTGCTCGCGGCCGAGGGTGGGCACGTCCAGGACAGGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PEP1

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8PGB5

References