Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3340871..3341396 Replicon chromosome
Accession NZ_CP024985
Organism Streptomyces lavendulae subsp. lavendulae strain CCM 3239

Toxin (Protein)


Gene name relE Uniprot ID A0A2K8PD81
Locus tag SLAV_RS14065 Protein ID WP_030226168.1
Coordinates 3341133..3341396 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S5UWF1
Locus tag SLAV_RS14060 Protein ID WP_019434848.1
Coordinates 3340871..3341140 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SLAV_RS14035 3336447..3337667 - 1221 WP_100660879.1 hypothetical protein -
SLAV_RS14040 3337759..3338196 - 438 WP_199922123.1 MarR family transcriptional regulator -
SLAV_RS14045 3338274..3339287 + 1014 WP_030226158.1 SMP-30/gluconolactonase/LRE family protein -
SLAV_RS14050 3339421..3340035 + 615 WP_051840334.1 DUF308 domain-containing protein -
SLAV_RS14055 3340172..3340417 + 246 WP_030226163.1 hypothetical protein -
SLAV_RS14060 3340871..3341140 + 270 WP_019434848.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SLAV_RS14065 3341133..3341396 + 264 WP_030226168.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SLAV_RS14070 3341504..3342673 + 1170 WP_030226170.1 hypothetical protein -
SLAV_RS14080 3343180..3344856 + 1677 WP_030226173.1 Eco57I restriction-modification methylase domain-containing protein -
SLAV_RS14085 3344870..3345619 + 750 WP_030226176.1 type II site-specific deoxyribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10084.54 Da        Isoelectric Point: 8.5042

>T89417 WP_030226168.1 NZ_CP024985:3341133-3341396 [Streptomyces lavendulae subsp. lavendulae]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELESDPLGFNTTALVSQPERRRLRVGDYRVLYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T89417 NZ_CP024985:3341133-3341396 [Streptomyces lavendulae subsp. lavendulae]
GTGAGTGAGTACCGCACCGTCTTCCGACCCGAGGCGCAGGCCGAGCTTCGGAAGATCCCTCGCGACATGGCACTGCGCAT
CCTCGCCAAGCTGACCGAGCTGGAGAGCGACCCCCTCGGCTTCAACACCACCGCACTCGTGTCCCAGCCCGAACGTCGTC
GCCTACGAGTGGGCGACTATCGCGTCCTCTACACCATCGACAACGGCGAGCTGGTGGTCTGGGTGGTTCACGTCGGACAC
CGCTCCACCGTTTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10259.71 Da        Isoelectric Point: 4.6265

>AT89417 WP_019434848.1 NZ_CP024985:3340871-3341140 [Streptomyces lavendulae subsp. lavendulae]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT89417 NZ_CP024985:3340871-3341140 [Streptomyces lavendulae subsp. lavendulae]
ATGACGCAGCCGCTGCCCATAGAGTCCATCCGCGACGTGCGCGCCCACCTGGCGGAAGTAGTGGAGCGCGCTGACCGTGA
CGACGTACCCACAGTCATCACCCGCCGAGGTAAGGAAGTCGCCGCTGTCGTCTCTATCGAGGTGCTGCGCAAGTACCAGG
AATGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCTCCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8PD81

Antitoxin

Source ID Structure
AlphaFold DB S5UWF1

References