Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1625166..1625998 Replicon chromosome
Accession NZ_CP024978
Organism Escherichia coli strain CV839-15

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag CV83915_RS11235 Protein ID WP_000854753.1
Coordinates 1625166..1625540 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID V0ULY5
Locus tag CV83915_RS11240 Protein ID WP_001315620.1
Coordinates 1625630..1625998 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV83915_RS11190 1620381..1621487 + 1107 WP_001315214.1 N-acetylneuraminate epimerase -
CV83915_RS11195 1621552..1622532 + 981 WP_001295601.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
CV83915_RS11200 1622540..1623190 - 651 WP_001037966.1 HNH endonuclease -
CV83915_RS29455 1624235..1624387 - 153 WP_001280445.1 hypothetical protein -
CV83915_RS11225 1624472..1624669 - 198 WP_000839281.1 DUF957 domain-containing protein -
CV83915_RS11230 1624681..1625169 - 489 WP_000777547.1 hypothetical protein -
CV83915_RS11235 1625166..1625540 - 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
CV83915_RS11240 1625630..1625998 - 369 WP_001315620.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CV83915_RS11245 1626161..1626382 - 222 WP_063079229.1 DUF987 domain-containing protein -
CV83915_RS11250 1626445..1626921 - 477 WP_001186774.1 RadC family protein -
CV83915_RS11255 1626937..1627422 - 486 WP_000849588.1 antirestriction protein -
CV83915_RS11260 1627477..1628295 - 819 WP_001234620.1 DUF945 domain-containing protein -
CV83915_RS11270 1628395..1628628 - 234 WP_001119729.1 DUF905 family protein -
CV83915_RS11275 1628707..1629162 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T89396 WP_000854753.1 NZ_CP024978:c1625540-1625166 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T89396 NZ_CP024978:c1625540-1625166 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13474.20 Da        Isoelectric Point: 6.2050

>AT89396 WP_001315620.1 NZ_CP024978:c1625998-1625630 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT89396 NZ_CP024978:c1625998-1625630 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB V0ULY5

References