89376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 4293..4840 Replicon plasmid pCV839-15-p1
Accession NZ_CP024975
Organism Escherichia coli strain CV839-15

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CV83915_RS00045 Protein ID WP_000969996.1
Coordinates 4559..4840 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CV83915_RS00040 Protein ID WP_000079941.1
Coordinates 4293..4562 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV83915_RS00005 4..153 - 150 Protein_0 transposase -
CV83915_RS00010 660..878 + 219 WP_001353651.1 heat-stable enterotoxin ST-I group a -
CV83915_RS00030 2462..2854 - 393 Protein_3 IS21-like element IS21 family helper ATPase IstB -
CV83915_RS00035 2854..4026 - 1173 WP_015056461.1 IS21 family transposase -
CV83915_RS00040 4293..4562 + 270 WP_000079941.1 hypothetical protein Antitoxin
CV83915_RS00045 4559..4840 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CV83915_RS00050 5149..6291 + 1143 WP_158649904.1 hypothetical protein -
CV83915_RS00065 8784..9179 - 396 WP_000445930.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - estIa 1..86835 86835
- inside IScluster/Tn - - 2420..8494 6074


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T89376 WP_000969996.1 NZ_CP024975:4559-4840 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T89376 NZ_CP024975:4559-4840 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCAAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAATGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTG
TATATTCTGCGAGTGTTGCATACAGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT89376 WP_000079941.1 NZ_CP024975:4293-4562 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT89376 NZ_CP024975:4293-4562 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCGGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCTCATGACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References