Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2495874..2496478 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name hicA Uniprot ID A0A0N0DNR4
Locus tag CVO91_RS12655 Protein ID WP_002941795.1
Coordinates 2496287..2496478 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Z8F1F3
Locus tag CVO91_RS12650 Protein ID WP_002941801.1
Coordinates 2495874..2496251 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS12630 2491550..2492089 - 540 WP_002941818.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
CVO91_RS12635 2492099..2492956 - 858 WP_002941812.1 helix-turn-helix domain-containing protein -
CVO91_RS12640 2493038..2494321 - 1284 WP_002941810.1 insulinase family protein -
CVO91_RS12645 2494318..2495571 - 1254 WP_002941805.1 insulinase family protein -
CVO91_RS12650 2495874..2496251 - 378 WP_002941801.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CVO91_RS12655 2496287..2496478 - 192 WP_002941795.1 type II toxin-antitoxin system HicA family toxin Toxin
CVO91_RS12660 2496647..2497054 - 408 WP_033875540.1 ArpU family transcriptional regulator -
CVO91_RS12665 2497069..2497230 - 162 WP_123921730.1 sigma-70 region 4 domain-containing protein -
CVO91_RS12675 2497893..2499269 + 1377 WP_100664963.1 IS1182 family transposase -
CVO91_RS12680 2499359..2499928 - 570 WP_100664964.1 hypothetical protein -
CVO91_RS13185 2499949..2500122 - 174 WP_002941785.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2488426..2511278 22852
- flank IS/Tn - - 2497893..2499269 1376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-106)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6989.26 Da        Isoelectric Point: 10.5552

>T89375 WP_002941795.1 NZ_CP024974:c2496478-2496287 [Streptococcus suis]
MPLTGKEMAKLAEANGWKEIRVNGSHHHFKKEGFSKIVTIPVHGNKDLGKGLEKKILKDLGLL

Download         Length: 192 bp

>T89375 NZ_CP024974:c2496478-2496287 [Streptococcus suis]
ATGCCACTTACTGGAAAAGAAATGGCAAAACTTGCAGAGGCTAACGGGTGGAAAGAAATCCGAGTTAATGGAAGTCACCA
CCATTTCAAAAAAGAAGGATTTTCAAAAATAGTCACAATCCCAGTTCATGGAAACAAGGATTTGGGAAAAGGGCTAGAAA
AGAAAATCCTGAAAGATTTGGGGCTACTTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14181.00 Da        Isoelectric Point: 4.2621

>AT89375 WP_002941801.1 NZ_CP024974:c2496251-2495874 [Streptococcus suis]
MLKSYPAIFHKDEQGYWVEFPEFSGGTQGDNLEEAMYNAREFLESSIALYIDEGMELPKASDIKELSAPDGFVSMIQADP
TPYIKNNKAIRKNVTVPEWLTKLADREGLNYSEILTTALETRLQV

Download         Length: 378 bp

>AT89375 NZ_CP024974:c2496251-2495874 [Streptococcus suis]
ATGTTAAAATCTTACCCAGCTATTTTTCATAAAGACGAACAAGGTTATTGGGTGGAGTTCCCAGAGTTTAGTGGTGGTAC
TCAAGGGGATAACCTTGAGGAAGCTATGTACAATGCCCGTGAGTTTTTAGAAAGCTCTATTGCCCTTTATATTGATGAGG
GGATGGAGTTACCAAAAGCAAGCGATATAAAGGAGTTAAGCGCTCCTGATGGCTTTGTTTCAATGATACAAGCTGACCCA
ACACCGTATATTAAGAATAATAAAGCAATTAGAAAGAATGTGACGGTGCCTGAATGGTTAACAAAACTAGCAGACCGTGA
GGGTTTGAACTATTCGGAAATTTTAACAACGGCTTTAGAAACACGATTACAAGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0DNR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8F1F3

References