Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2409705..2410323 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name relE Uniprot ID A0A2I5KID3
Locus tag CVO91_RS12155 Protein ID WP_002942018.1
Coordinates 2409982..2410323 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I5KIF7
Locus tag CVO91_RS12150 Protein ID WP_002942019.1
Coordinates 2409705..2409992 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS12125 2405962..2406885 - 924 WP_002942036.1 zinc ABC transporter substrate-binding protein -
CVO91_RS12130 2407011..2407670 + 660 WP_002942034.1 metal-dependent transcriptional regulator -
CVO91_RS12135 2407683..2407958 - 276 WP_002942033.1 hypothetical protein -
CVO91_RS12140 2408055..2408729 - 675 WP_002942030.1 CPBP family intramembrane metalloprotease -
CVO91_RS13280 2409045..2409464 - 420 WP_002942022.1 hypothetical protein -
CVO91_RS12150 2409705..2409992 + 288 WP_002942019.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CVO91_RS12155 2409982..2410323 + 342 WP_002942018.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVO91_RS12160 2410418..2410612 - 195 WP_002942017.1 hypothetical protein -
CVO91_RS12165 2410634..2411299 - 666 WP_100198749.1 CPBP family intramembrane metalloprotease -
CVO91_RS12170 2411339..2411563 - 225 WP_002942015.1 hypothetical protein -
CVO91_RS12175 2411586..2411792 - 207 WP_002942014.1 hypothetical protein -
CVO91_RS13170 2411818..2411979 - 162 WP_002942013.1 hypothetical protein -
CVO91_RS12180 2412007..2412216 - 210 WP_002942010.1 hypothetical protein -
CVO91_RS13175 2412528..2412695 - 168 WP_002942007.1 hypothetical protein -
CVO91_RS13180 2412769..2412930 - 162 WP_002942006.1 hypothetical protein -
CVO91_RS12190 2412971..2413129 - 159 WP_002942002.1 hypothetical protein -
CVO91_RS12195 2413291..2414628 - 1338 WP_002941998.1 GHKL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.19 Da        Isoelectric Point: 9.5737

>T89374 WP_002942018.1 NZ_CP024974:2409982-2410323 [Streptococcus suis]
MVYEVHLSAKAEQDLEEIYQYYVREFSKSSARKVLASLSTAILTLEIFPEGYIDLDARLGRALFPEGKTRMIPGKQHLIF
YLIRGSRVDILRIRGARTDYLNNLDNLFKQTLK

Download         Length: 342 bp

>T89374 NZ_CP024974:2409982-2410323 [Streptococcus suis]
ATGGTCTATGAAGTACATTTATCTGCTAAAGCCGAACAAGATTTAGAGGAAATCTACCAGTACTATGTCCGTGAATTTTC
AAAATCAAGTGCTCGAAAGGTGCTTGCATCTCTGAGCACAGCTATCTTGACCTTAGAAATATTTCCAGAGGGATATATTG
ACCTCGACGCTCGTCTGGGACGAGCATTGTTCCCAGAAGGAAAAACAAGGATGATTCCTGGAAAACAGCACCTCATCTTC
TATTTGATTCGCGGCTCTCGTGTAGATATCCTTCGCATTAGAGGAGCAAGGACAGACTACCTAAACAACCTAGACAATCT
ATTCAAGCAAACCCTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10794.20 Da        Isoelectric Point: 4.1952

>AT89374 WP_002942019.1 NZ_CP024974:2409705-2409992 [Streptococcus suis]
MAGLVRDRQYNFRVNAQLLEQAKIILSEKDMTLSDALNLFVERVVEEQDLPIKTVEEAHAEAFLDELIAELDEGYQEVLS
GHTTPAREVFAKYGL

Download         Length: 288 bp

>AT89374 NZ_CP024974:2409705-2409992 [Streptococcus suis]
ATGGCAGGATTGGTTAGGGATAGACAATATAATTTTAGAGTAAATGCACAATTATTGGAACAAGCAAAAATAATCTTATC
AGAAAAAGATATGACCCTTTCTGATGCTCTTAATTTATTTGTAGAAAGGGTGGTTGAAGAGCAAGATTTGCCAATAAAAA
CGGTTGAAGAGGCACATGCAGAGGCTTTTCTAGATGAGTTGATTGCAGAGCTTGATGAAGGCTACCAAGAAGTTTTATCA
GGACACACAACACCTGCTCGTGAGGTATTCGCCAAATATGGTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5KID3

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5KIF7

References