Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2286635..2287241 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name parE Uniprot ID A0A2I5KI54
Locus tag CVO91_RS11590 Protein ID WP_002940309.1
Coordinates 2286635..2286964 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0Z8LVV9
Locus tag CVO91_RS11595 Protein ID WP_002940311.1
Coordinates 2286954..2287241 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS11560 2283143..2284051 - 909 WP_079255266.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CVO91_RS11565 2284035..2284565 - 531 WP_002940287.1 DUF1697 domain-containing protein -
CVO91_RS11570 2284579..2284836 - 258 WP_002940288.1 Txe/YoeB family addiction module toxin -
CVO91_RS11575 2284838..2285098 - 261 WP_002940290.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CVO91_RS11580 2285612..2286067 - 456 WP_002940299.1 8-oxo-dGTP diphosphatase -
CVO91_RS11585 2286075..2286623 - 549 WP_033875378.1 hypothetical protein -
CVO91_RS11590 2286635..2286964 - 330 WP_002940309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVO91_RS11595 2286954..2287241 - 288 WP_002940311.1 hypothetical protein Antitoxin
CVO91_RS11600 2287338..2287718 - 381 WP_002940320.1 hypothetical protein -
CVO91_RS11605 2287711..2288280 - 570 WP_002940322.1 ribonuclease M5 -
CVO91_RS11610 2288264..2289046 - 783 WP_002940323.1 TatD family hydrolase -
CVO91_RS11615 2289153..2289290 - 138 WP_002939016.1 50S ribosomal protein L34 -
CVO91_RS11620 2289458..2290453 - 996 WP_002940330.1 protein jag -
CVO91_RS11625 2290473..2291285 - 813 WP_002940331.1 YidC/Oxa1 family membrane protein insertase -
CVO91_RS11630 2291269..2291628 - 360 WP_002940332.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-96)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12590.57 Da        Isoelectric Point: 7.1991

>T89373 WP_002940309.1 NZ_CP024974:c2286964-2286635 [Streptococcus suis]
MEFESYSVILAPAVEKELAVIYAYFSEQFSEEIAKRRIGMIVQALESLQIFPERGFNADNRFGKQIDPPHLTRGYVIGKD
YIALYRVVEKEVRVGHLFATKSDYVKLLK

Download         Length: 330 bp

>T89373 NZ_CP024974:c2286964-2286635 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAGTTGGCAGTTATTTACGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCCAAGCTTTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTGACCCGAGGTTACGTTATTGGAAAAGAC
TACATTGCACTCTATCGTGTGGTCGAAAAAGAAGTGCGAGTTGGTCATCTCTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10911.52 Da        Isoelectric Point: 4.3472

>AT89373 WP_002940311.1 NZ_CP024974:c2287241-2286954 [Streptococcus suis]
MITIKKDAQVNFKTDSRLLEKAKEIFAMNQLDLTAGFNLFLQNIAVKNELPILTEEELEREELFLQLQKEIQENQQAIEA
GQGISLESVKEKYGI

Download         Length: 288 bp

>AT89373 NZ_CP024974:c2287241-2286954 [Streptococcus suis]
TTGATAACTATAAAAAAAGATGCCCAAGTAAATTTCAAAACCGATTCCAGACTTTTGGAAAAAGCCAAGGAAATATTTGC
TATGAACCAGTTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATTGCTGTAAAAAATGAGTTGCCCATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAACTTCAAAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCAAGGGATCAGCCTAGAAAGCGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I5KI54

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8LVV9

References