Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1328419..1329199 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag CVO91_RS06815 Protein ID WP_100664819.1
Coordinates 1328419..1328925 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag CVO91_RS06820 Protein ID WP_000301765.1
Coordinates 1328927..1329199 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS06795 1323634..1323807 - 174 WP_011528024.1 cysteine-rich KTR domain-containing protein -
CVO91_RS06800 1323859..1325778 - 1920 WP_100664818.1 tetracycline resistance ribosomal protection protein Tet(O) -
CVO91_RS06805 1326145..1326519 - 375 WP_001140406.1 TnpV protein -
CVO91_RS06810 1326500..1328446 - 1947 Protein_1255 DEAD/DEAH box helicase family protein -
CVO91_RS06815 1328419..1328925 - 507 WP_100664819.1 zeta toxin family protein Toxin
CVO91_RS06820 1328927..1329199 - 273 WP_000301765.1 antitoxin Antitoxin
CVO91_RS06825 1329216..1329425 - 210 WP_000527317.1 peptide-binding protein -
CVO91_RS06830 1329544..1330077 - 534 WP_079396257.1 ParA family protein -
CVO91_RS06835 1330068..1330862 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
CVO91_RS06840 1330955..1331387 - 433 Protein_1261 GNAT family N-acetyltransferase -
CVO91_RS06845 1331562..1331846 - 285 WP_073459356.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
CVO91_RS06855 1331992..1332729 - 738 WP_100664820.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
CVO91_RS06860 1332854..1332949 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
CVO91_RS06865 1332970..1333134 - 165 WP_002935077.1 peptide-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aph(3')-III / tet(O) / erm(B) - 1231627..1339688 108061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-161)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18757.25 Da        Isoelectric Point: 4.8381

>T89371 WP_100664819.1 NZ_CP024974:c1328925-1328419 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKIESYLGTIERYE
SLPTPIPT

Download         Length: 507 bp

>T89371 NZ_CP024974:c1328925-1328419 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
AGTTTGCCTACACCTATTCCAACGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT89371 WP_000301765.1 NZ_CP024974:c1329199-1328927 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT89371 NZ_CP024974:c1329199-1328927 [Streptococcus suis]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References