Detailed information of TA system TA089371

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1328419..1329199
• Replicon: chromosome
• Accession: NZ_CP024974
• Organism: Streptococcus suis strain CZ130302

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: CVO91_RS06815
• Protein ID: WP_100664819.1
• Coordinates: 1328419..1328925 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: R2XCR7
• Locus tag: CVO91_RS06820
• Protein ID: WP_000301765.1
• Coordinates: 1328927..1329199 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVO91_RS06795	1323634..1323807	-	174	WP_011528024.1	cysteine-rich KTR domain-containing protein	-
CVO91_RS06800	1323859..1325778	-	1920	WP_100664818.1	tetracycline resistance ribosomal protection protein Tet(O)	-
CVO91_RS06805	1326145..1326519	-	375	WP_001140406.1	TnpV protein	-
CVO91_RS06810	1326500..1328446	-	1947	Protein_1255	DEAD/DEAH box helicase family protein	-
CVO91_RS06815	1328419..1328925	-	507	WP_100664819.1	zeta toxin family protein	Toxin
CVO91_RS06820	1328927..1329199	-	273	WP_000301765.1	antitoxin	Antitoxin
CVO91_RS06825	1329216..1329425	-	210	WP_000527317.1	peptide-binding protein	-
CVO91_RS06830	1329544..1330077	-	534	WP_079396257.1	ParA family protein	-
CVO91_RS06835	1330068..1330862	-	795	WP_001096887.1	aminoglycoside O-phosphotransferase APH(3')-IIIa	-
CVO91_RS06840	1330955..1331387	-	433	Protein_1261	GNAT family N-acetyltransferase	-
CVO91_RS06845	1331562..1331846	-	285	WP_073459356.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
CVO91_RS06855	1331992..1332729	-	738	WP_100664820.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
CVO91_RS06860	1332854..1332949	-	96	WP_001809736.1	23S rRNA methyltransferase attenuation leader peptide	-
CVO91_RS06865	1332970..1333134	-	165	WP_002935077.1	peptide-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aph(3')-III / tet(O) / erm(B)	-	1231627..1339688	108061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-161)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18757.25 Da
• Isoelectric Point: 4.8381

>T89371 WP_100664819.1 NZ_CP024974:c1328925-1328419 [Streptococcus suis]
MANIVNFTDKQFENRLNDNLEELVQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKIESYLGTIERYE
SLPTPIPT

Nucleotide

• Length: 507 bp

>T89371 NZ_CP024974:c1328925-1328419 [Streptococcus suis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCGAAAATTGAATCATACTTAGGAACAATTGAACGATATGAA
AGTTTGCCTACACCTATTCCAACGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10721.25 Da
• Isoelectric Point: 6.4676

>AT89371 WP_000301765.1 NZ_CP024974:c1329199-1328927 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Nucleotide

• Length: 273 bp

>AT89371 NZ_CP024974:c1329199-1328927 [Streptococcus suis]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829F0A3