Detailed information of TA system TA089370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1311207..1311750
• Replicon: chromosome
• Accession: NZ_CP024974
• Organism: Streptococcus suis strain CZ130302

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: A0A1X9I2P4
• Locus tag: CVO91_RS06690
• Protein ID: WP_002943355.1
• Coordinates: 1311207..1311476 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: Q9AL19
• Locus tag: CVO91_RS06695
• Protein ID: WP_002326825.1
• Coordinates: 1311478..1311750 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVO91_RS06655	1307860..1308128	-	269	Protein_1227	hypothetical protein	-
CVO91_RS06660	1308221..1309108	+	888	WP_029176741.1	tyrosine-type recombinase/integrase	-
CVO91_RS06665	1309153..1309452	-	300	WP_024418319.1	hypothetical protein	-
CVO91_RS06670	1309466..1309765	-	300	WP_029176742.1	hypothetical protein	-
CVO91_RS06675	1309836..1310795	-	960	Protein_1231	hypothetical protein	-
CVO91_RS06680	1310788..1311109	-	322	Protein_1232	DUF4368 domain-containing protein	-
CVO91_RS06690	1311207..1311476	-	270	WP_002943355.1	zeta toxin family protein	Toxin
CVO91_RS06695	1311478..1311750	-	273	WP_002326825.1	antitoxin	Antitoxin
CVO91_RS06700	1311768..1311977	-	210	WP_000527318.1	peptide-binding protein	-
CVO91_RS06705	1312075..1312608	-	534	WP_100664816.1	ParA family protein	-
CVO91_RS06710	1312599..1313393	-	795	WP_001096887.1	aminoglycoside O-phosphotransferase APH(3')-IIIa	-
CVO91_RS06715	1313486..1313918	-	433	Protein_1238	GNAT family N-acetyltransferase	-
CVO91_RS06725	1314324..1314407	-	84	WP_001814874.1	23S rRNA methyltransferase attenuation leader peptide	-
CVO91_RS06730	1314456..1314695	-	240	WP_000635249.1	peptide-binding protein	-
CVO91_RS06735	1314770..1315873	-	1104	Protein_1241	recombinase family protein	-
CVO91_RS06740	1315927..1316118	-	192	WP_000503424.1	hypothetical protein	-
CVO91_RS06745	1316189..1316419	-	231	WP_000659121.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aph(3')-III / tet(O) / erm(B)	-	1231627..1339688	108061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-75)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 9999.08 Da
• Isoelectric Point: 8.7696

>T89370 WP_002943355.1 NZ_CP024974:c1311476-1311207 [Streptococcus suis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPRSTFAN
VNKRNNFNS

Nucleotide

• Length: 270 bp

>T89370 NZ_CP024974:c1311476-1311207 [Streptococcus suis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAGAAGCACGTTCGCCAAT
GTCAACAAGAGAAATAACTTTAACAGTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10720.17 Da
• Isoelectric Point: 4.4865

>AT89370 WP_002326825.1 NZ_CP024974:c1311750-1311478 [Streptococcus suis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Nucleotide

• Length: 273 bp

>AT89370 NZ_CP024974:c1311750-1311478 [Streptococcus suis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A1X9I2P4

Antitoxin

• AlphaFold DB: A0A0M2AF93