Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1268108..1268609 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8G8W5
Locus tag CVO91_RS06440 Protein ID WP_002943249.1
Coordinates 1268108..1268374 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I5KFM1
Locus tag CVO91_RS06445 Protein ID WP_002943256.1
Coordinates 1268358..1268609 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS06410 1263203..1263482 + 280 Protein_1180 hypothetical protein -
CVO91_RS06420 1263745..1264815 + 1071 WP_002943231.1 tyrosine recombinase XerS -
CVO91_RS06425 1264878..1266386 - 1509 WP_002943240.1 phosphoglucomutase -
CVO91_RS06430 1266463..1267404 - 942 WP_002943243.1 sensor histidine kinase -
CVO91_RS06435 1267401..1268066 - 666 WP_002943246.1 response regulator transcription factor -
CVO91_RS06440 1268108..1268374 - 267 WP_002943249.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CVO91_RS06445 1268358..1268609 - 252 WP_002943256.1 hypothetical protein Antitoxin
CVO91_RS06450 1268702..1270672 - 1971 WP_002943273.1 FtsX-like permease family protein -
CVO91_RS06455 1270673..1271425 - 753 WP_002943274.1 ABC transporter ATP-binding protein -
CVO91_RS06460 1271561..1272295 - 735 WP_002943275.1 ABC transporter permease -
CVO91_RS06465 1272297..1273043 - 747 WP_002943276.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aph(3')-III / tet(O) / erm(B) - 1231627..1339688 108061


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-87)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10362.05 Da        Isoelectric Point: 10.6122

>T89369 WP_002943249.1 NZ_CP024974:c1268374-1268108 [Streptococcus suis]
MKTCYKLVPTGRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVSIEDDKLIVTALEV
GHRKEIYK

Download         Length: 267 bp

>T89369 NZ_CP024974:c1268374-1268108 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCAACTGGTCGTTTTATCAAACAGTTGAAAAAGCTAGACAAATTTACTCAAAAGCA
GATTACCAACTACCTGTCTAGTCATGTGACCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAACTACAGGGTTATCGTCAGTATTGAAGATGACAAATTGATTGTAACGGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9496.70 Da        Isoelectric Point: 3.6861

>AT89369 WP_002943256.1 NZ_CP024974:c1268609-1268358 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIAWAEYQEDLANGIEPISWEEMLEELELTNE
DLL

Download         Length: 252 bp

>AT89369 NZ_CP024974:c1268609-1268358 [Streptococcus suis]
ATGGCAGCTATTACATTGAAGGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGCTT
ATCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGATGAGTACGATGCGCGTGTGGCAGACATAGCTTGGGCAG
AATACCAAGAAGACTTGGCGAATGGAATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGAGTTGACGAATGAA
GACCTGTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8G8W5

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5KFM1

References