Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 607005..607674 Replicon chromosome
Accession NZ_CP024974
Organism Streptococcus suis strain CZ130302

Toxin (Protein)


Gene name hicA Uniprot ID G7SGM1
Locus tag CVO91_RS03330 Protein ID WP_014637653.1
Coordinates 607005..607187 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2I5KE28
Locus tag CVO91_RS03335 Protein ID WP_004298783.1
Coordinates 607225..607674 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVO91_RS03300 602374..604743 + 2370 WP_100664755.1 ribonuclease R -
CVO91_RS03305 604746..605213 + 468 WP_002935771.1 SsrA-binding protein SmpB -
CVO91_RS03310 605490..605708 + 219 WP_100198753.1 hypothetical protein -
CVO91_RS03315 606113..606577 + 465 WP_002939996.1 IS200/IS605-like element ISSsu4 family transposase -
CVO91_RS03330 607005..607187 + 183 WP_014637653.1 type II toxin-antitoxin system HicA family toxin Toxin
CVO91_RS03335 607225..607674 + 450 WP_004298783.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CVO91_RS03340 607835..608878 - 1044 WP_033875574.1 Zn-dependent alcohol dehydrogenase -
CVO91_RS03345 609032..609892 + 861 WP_004298787.1 SAM-dependent methyltransferase TehB -
CVO91_RS03350 609981..611855 + 1875 WP_100664756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 605490..618568 13078
- flank IS/Tn - - 606113..606577 464


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6653.87 Da        Isoelectric Point: 10.8207

>T89368 WP_014637653.1 NZ_CP024974:607005-607187 [Streptococcus suis]
MPMTQKEMVKLLTAHGWTKTKGGKGSHVKLEKAGERPITIPHGEINKYTERGIKKQAGLL

Download         Length: 183 bp

>T89368 NZ_CP024974:607005-607187 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16638.66 Da        Isoelectric Point: 4.0193

>AT89368 WP_004298783.1 NZ_CP024974:607225-607674 [Streptococcus suis]
MLVTYPALFYFDDTDGANAPYFVTFPDFEHSATQGEDMADAMAMASDWLGMNLADYIENGRDIPTPSSINTLSLVDNNPF
RNEDFEMVYDSSKSFISMVMVDVAKYLGSQEPVKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKLHA

Download         Length: 450 bp

>AT89368 NZ_CP024974:607225-607674 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATTGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAACTTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G7SGM1

Antitoxin

Source ID Structure
AlphaFold DB A0A2I5KE28

References