Detailed information of TA system TA089367

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-HTH_XRE
• Location: 294874..296135
• Replicon: chromosome
• Accession: NZ_CP024974
• Organism: Streptococcus suis strain CZ130302

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A2I5KD69
• Locus tag: CVO91_RS01655
• Protein ID: WP_002941114.1
• Coordinates: 295350..296135 (+)
• Length: 262 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: CVO91_RS01650
• Protein ID: WP_002941113.1
• Coordinates: 294874..295350 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVO91_RS01615	290193..290573	+	381	WP_002941098.1	CidA/LrgA family protein	-
CVO91_RS01620	290566..291261	+	696	WP_002937552.1	LrgB family protein	-
CVO91_RS01625	291295..292095	-	801	WP_002941103.1	formate/nitrite transporter family protein	-
CVO91_RS01630	292234..293079	+	846	WP_002941107.1	aquaporin family protein	-
CVO91_RS01635	293269..293463	+	195	Protein_272	DUF853 family protein	-
CVO91_RS01640	293572..294186	+	615	WP_002941111.1	CoA pyrophosphatase	-
CVO91_RS01650	294874..295350	+	477	WP_002941113.1	helix-turn-helix domain-containing protein	Antitoxin
CVO91_RS01655	295350..296135	+	786	WP_002941114.1	zeta toxin family protein	Toxin
CVO91_RS01660	296154..297050	+	897	WP_002941116.1	hypothetical protein	-
CVO91_RS01665	297066..297590	+	525	WP_002941117.1	hypothetical protein	-
CVO91_RS01670	297674..298066	+	393	WP_002941122.1	ImmA/IrrE family metallo-endopeptidase	-
CVO91_RS01675	298056..298259	+	204	WP_033875445.1	hypothetical protein	-
CVO91_RS01680	298392..299159	+	768	WP_002941124.1	DeoR/GlpR family DNA-binding transcription regulator	-
CVO91_RS01685	299346..299809	+	464	Protein_281	IS200/IS605 family transposase	-
CVO91_RS01700	300119..300541	+	423	WP_002941127.1	galactose-6-phosphate isomerase subunit LacA	-
CVO91_RS01705	300568..301083	+	516	WP_002941130.1	galactose-6-phosphate isomerase subunit LacB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	299346..299684	338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (28-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 262 a.a.
• Molecular weight: 29476.36 Da
• Isoelectric Point: 6.2486

>T89367 WP_002941114.1 NZ_CP024974:295350-296135 [Streptococcus suis]
MRLEEFSEAEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDGLSTQGYHLLIEGTLRTTQVPRQTAQLLVSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAVDPTQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSKTDDGSAAEVLQNCLFGEWSKVEEAMF
KMGQERLRELSKSNGNDVLMS

Nucleotide

• Length: 786 bp

>T89367 NZ_CP024974:295350-296135 [Streptococcus suis]
ATGAGGTTGGAAGAATTCAGTGAGGCTGAGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
AATCCCAGATCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGGACTCAGCAC
GCAGGGGTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCAA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTTAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCGTAGATCCAACTCAGGCCAGAGCAACACCAAAAGAACACCACGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTTGAAAGCGATAAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
AAACGGATGATGGTTCTGCAGCAGAAGTTCTTCAAAATTGCCTTTTCGGAGAGTGGAGTAAAGTAGAGGAGGCGATGTTT
AAGATGGGGCAGGAACGGTTGAGGGAGTTGAGTAAAAGTAATGGAAACGATGTATTGATGAGTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18282.68 Da
• Isoelectric Point: 4.4036

>AT89367 WP_002941113.1 NZ_CP024974:294874-295350 [Streptococcus suis]
MIGENIKTLRHTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Nucleotide

• Length: 477 bp

>AT89367 NZ_CP024974:294874-295350 [Streptococcus suis]
ATGATCGGAGAAAATATAAAAACACTACGCCATACACATGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCTGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAAGATATTGCTTTTGATGATGA
ATCCAACCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACAAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A2I5KD69