Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 6723992..6725023 Replicon chromosome
Accession NZ_CP024972
Organism Amycolatopsis sp. TNS106

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CVV72_RS30870 Protein ID WP_219147280.1
Coordinates 6724451..6725023 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CVV72_RS30865 Protein ID WP_219147278.1
Coordinates 6723992..6724447 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVV72_RS30840 (CVV72_30700) 6719500..6720570 + 1071 WP_219147270.1 phosphoribosylformylglycinamidine cyclo-ligase -
CVV72_RS30845 (CVV72_30705) 6720724..6721155 + 432 WP_255632311.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
CVV72_RS30850 (CVV72_30710) 6721161..6721919 - 759 WP_219147272.1 GNAT family N-acetyltransferase -
CVV72_RS30855 (CVV72_30715) 6722097..6722747 - 651 WP_219147274.1 VanZ family protein -
CVV72_RS30860 (CVV72_30720) 6722970..6723869 - 900 WP_219147276.1 Gfo/Idh/MocA family oxidoreductase -
CVV72_RS30865 (CVV72_30725) 6723992..6724447 + 456 WP_219147278.1 helix-turn-helix domain-containing protein Antitoxin
CVV72_RS30870 (CVV72_30730) 6724451..6725023 + 573 WP_219147280.1 PIN domain-containing protein Toxin
CVV72_RS30875 (CVV72_30735) 6725014..6725874 - 861 WP_219147282.1 3-hydroxybutyryl-CoA dehydrogenase -
CVV72_RS30880 (CVV72_30740) 6725965..6726150 - 186 WP_007032561.1 DUF3073 domain-containing protein -
CVV72_RS30885 (CVV72_30745) 6726358..6727257 + 900 WP_219147284.1 hypothetical protein -
CVV72_RS30890 (CVV72_30750) 6727254..6728201 - 948 WP_219147286.1 asparaginase -
CVV72_RS30895 (CVV72_30755) 6728198..6728761 - 564 WP_219147288.1 aerial mycelium formation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-111)

Antitoxin

SinI-like, DNA-binding domain

(82-128)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21441.62 Da        Isoelectric Point: 5.1584

>T89365 WP_219147280.1 NZ_CP024972:6724451-6725023 [Amycolatopsis sp. TNS106]
VAFVVLFDANVLHPNVLRDLLLRIAQSGFVQAKWTDEILDEVFRNLRKNRPDLDPLKLDRTRSLMNAAVRDCLVKGYEPL
VTTLELPDPDDRHVLAAAIKAQARVIVTANLRDFPEQVLGRWNVEAQSADDFVLDRIELSERVVVEAVRRIVDARRAPPT
GVAEVLDALERCGLRKSVAALRRCEEGDQE

Download         Length: 573 bp

>T89365 NZ_CP024972:6724451-6725023 [Amycolatopsis sp. TNS106]
GTGGCCTTCGTCGTCCTTTTCGACGCCAACGTGCTGCACCCCAACGTTCTGCGTGATCTCCTGCTCCGGATCGCGCAGAG
CGGGTTCGTGCAGGCGAAGTGGACGGACGAGATCCTCGACGAAGTCTTCCGGAATCTCCGGAAGAACCGGCCCGATCTCG
ATCCGCTCAAACTCGACAGGACGCGGAGCCTGATGAACGCCGCTGTCCGGGACTGCCTGGTCAAGGGCTATGAACCGCTC
GTCACCACGCTCGAACTGCCAGACCCGGACGATCGGCACGTGCTCGCCGCGGCCATCAAGGCACAGGCGCGCGTCATCGT
GACCGCGAACTTGCGGGATTTCCCCGAACAGGTGCTCGGCCGCTGGAACGTCGAAGCCCAGAGCGCCGACGACTTCGTCC
TCGACCGGATCGAGCTCAGTGAGCGTGTGGTCGTGGAGGCGGTGCGGCGCATCGTCGACGCGCGCCGCGCTCCGCCTACC
GGCGTCGCCGAGGTTCTCGATGCTTTGGAGCGCTGCGGCCTGCGCAAGTCGGTCGCAGCGCTCCGTCGCTGTGAAGAAGG
AGATCAGGAGTAG

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16765.03 Da        Isoelectric Point: 5.2798

>AT89365 WP_219147278.1 NZ_CP024972:6723992-6724447 [Amycolatopsis sp. TNS106]
MTALTIDQIVPGRHDIDVALEALPHVEAYLARRHERDTVRVVVDENEESVVVPRGVVDLMARVLALVAAGESVSIVPSHA
ELTTQQAADLLNVSRPFLIGLLEAGRIEYRTVGKHRRVKAGSLHDYLREDDRRRRDAADELSALDQEMGLT

Download         Length: 456 bp

>AT89365 NZ_CP024972:6723992-6724447 [Amycolatopsis sp. TNS106]
ATGACTGCGTTGACCATCGACCAGATCGTCCCGGGACGCCACGACATCGACGTGGCACTCGAGGCACTTCCGCACGTCGA
GGCCTATCTGGCCAGGCGTCATGAACGGGACACCGTGCGCGTCGTCGTCGATGAGAACGAAGAGTCCGTGGTCGTGCCGC
GGGGAGTCGTCGATCTGATGGCCCGGGTGCTGGCGCTGGTGGCGGCAGGCGAGAGTGTGTCCATCGTCCCGTCACACGCG
GAACTGACCACACAGCAGGCGGCCGACCTGCTCAACGTTTCCCGGCCGTTCCTCATCGGGCTGCTGGAAGCGGGCCGGAT
CGAGTACCGCACGGTCGGCAAGCATCGTCGCGTGAAGGCCGGTTCCCTCCACGACTACCTGCGAGAAGACGACCGGCGAC
GCCGCGACGCCGCGGACGAACTTTCCGCCCTGGATCAGGAGATGGGGCTGACGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References