Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafQ-relB/YafQ-DinJ
Location 1292424..1292958 Replicon chromosome
Accession NZ_CP024959
Organism Bifidobacterium adolescentis strain P2P3

Toxin (Protein)


Gene name yafQ Uniprot ID A0A1E7Y0R6
Locus tag CV760_RS05730 Protein ID WP_070122450.1
Coordinates 1292677..1292958 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V8QB77
Locus tag CV760_RS05725 Protein ID WP_041777340.1
Coordinates 1292424..1292684 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV760_RS05710 1288451..1290226 + 1776 WP_070122448.1 glycoside hydrolase family 13 protein -
CV760_RS05715 1290280..1291647 + 1368 WP_080863173.1 ABC transporter substrate-binding protein -
CV760_RS05720 1291766..1292230 + 465 WP_124917234.1 D-aminoacyl-tRNA deacylase -
CV760_RS05725 1292424..1292684 + 261 WP_041777340.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CV760_RS05730 1292677..1292958 + 282 WP_070122450.1 type II toxin-antitoxin system YafQ family toxin Toxin
CV760_RS05735 1292977..1293174 - 198 WP_117320014.1 hypothetical protein -
CV760_RS05740 1293240..1295705 - 2466 WP_124917235.1 DUF4268 domain-containing protein -
CV760_RS05745 1295820..1296101 - 282 WP_026646055.1 hypothetical protein -
CV760_RS05750 1296085..1297176 - 1092 WP_164463198.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11180.89 Da        Isoelectric Point: 10.1547

>T89354 WP_070122450.1 NZ_CP024959:1292677-1292958 [Bifidobacterium adolescentis]
MLKSVFRTTQFKKDFKALLKKHYNPDKLRQAIDTLMAQDKQLLSTKYRDHQLTGSWRGYREIHIEGDWLVIYRVEKQELQ
LVLTRTGSHDDLF

Download         Length: 282 bp

>T89354 NZ_CP024959:1292677-1292958 [Bifidobacterium adolescentis]
ATGCTTAAGTCGGTTTTTCGCACAACGCAATTCAAAAAGGATTTCAAGGCTCTGCTTAAAAAGCATTACAATCCCGATAA
GCTTAGACAGGCCATCGACACGCTCATGGCCCAAGACAAACAGTTGCTCAGCACAAAATACCGCGACCATCAGCTGACCG
GAAGCTGGAGGGGATACCGCGAAATCCACATCGAGGGTGACTGGCTCGTCATTTACCGTGTGGAGAAGCAGGAGCTGCAA
CTCGTGCTCACACGGACCGGGTCGCATGATGATTTGTTCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9656.83 Da        Isoelectric Point: 4.6028

>AT89354 WP_041777340.1 NZ_CP024959:1292424-1292684 [Bifidobacterium adolescentis]
MSDTATISFRTDPAIKREAKELYADMGMDLSTAINIFLRQSIRENGMPFKITRDNPSSIEARRQAETHDGESFTSTDALM
KDLLDA

Download         Length: 261 bp

>AT89354 NZ_CP024959:1292424-1292684 [Bifidobacterium adolescentis]
ATGAGCGACACTGCGACGATCAGTTTCCGCACGGACCCAGCGATCAAGCGAGAGGCAAAGGAACTGTATGCCGATATGGG
CATGGATCTGTCAACGGCAATCAACATCTTTCTGCGCCAATCAATCCGCGAAAACGGCATGCCTTTCAAGATCACCAGGG
ACAATCCGTCCAGCATTGAGGCACGCCGCCAAGCGGAAACCCATGACGGAGAATCCTTCACCAGCACGGATGCGTTGATG
AAGGATCTGTTGGATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7Y0R6

Antitoxin

Source ID Structure
AlphaFold DB A0A1V8QB77

References