Detailed information of TA system TA089353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 297915..298486
• Replicon: chromosome
• Accession: NZ_CP024959
• Organism: Bifidobacterium adolescentis strain P2P3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CV760_RS01190
• Protein ID: WP_003807675.1
• Coordinates: 297915..298214 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C2Z6P7
• Locus tag: CV760_RS01195
• Protein ID: WP_034984155.1
• Coordinates: 298214..298486 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV760_RS01180	294599..295327	+	729	WP_124917050.1	type 1 glutamine amidotransferase	-
CV760_RS01185	295639..297816	+	2178	WP_124917051.1	ABC-F family ATP-binding cassette domain-containing protein	-
CV760_RS01190	297915..298214	-	300	WP_003807675.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CV760_RS01195	298214..298486	-	273	WP_034984155.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CV760_RS01200	298600..299529	-	930	WP_124917052.1	hypothetical protein	-
CV760_RS01205	299620..300159	+	540	WP_124917053.1	hypothetical protein	-
CV760_RS01210	300175..300975	-	801	WP_124917441.1	ATP-binding protein	-
CV760_RS01215	301305..301934	-	630	WP_003807685.1	response regulator transcription factor	-
CV760_RS01220	302071..302712	+	642	WP_085380731.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11662.09 Da
• Isoelectric Point: 8.0955

>T89353 WP_003807675.1 NZ_CP024959:c298214-297915 [Bifidobacterium adolescentis]
MGRLTADFAKAFSRDLKKNAKRRNWNLTELEKVIDLVVENTPETLEELRRRHNMHTLSGNWRGRYECHVANAGDWLVIWS
SNDSVAFFERTGSHDELFR

Nucleotide

• Length: 300 bp

>T89353 NZ_CP024959:c298214-297915 [Bifidobacterium adolescentis]
ATGGGCCGGTTGACCGCCGACTTCGCGAAGGCCTTCAGCCGCGATCTGAAAAAGAACGCCAAACGGCGTAACTGGAACCT
GACCGAACTTGAAAAAGTCATCGATCTGGTAGTGGAGAACACCCCGGAAACGCTGGAGGAGCTGCGCCGCCGCCACAACA
TGCACACCCTGTCCGGCAATTGGCGCGGGCGATACGAATGCCATGTCGCCAATGCCGGGGACTGGCTAGTGATCTGGTCA
TCGAACGATTCAGTCGCATTCTTCGAACGCACCGGCAGCCACGACGAATTATTCCGCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9714.91 Da
• Isoelectric Point: 4.5535

>AT89353 WP_034984155.1 NZ_CP024959:c298486-298214 [Bifidobacterium adolescentis]
MSASTLTIRMDDELKRSAADVAEYYGLDLSSVVRAVFKQMVNTGRIPLTFAPEEPNGESLNAAAEADSFMASGKTGRFTN
GHDLLEAAMR

Nucleotide

• Length: 273 bp

>AT89353 NZ_CP024959:c298486-298214 [Bifidobacterium adolescentis]
ATGAGTGCATCAACGTTGACCATACGGATGGATGACGAACTCAAGCGTTCGGCCGCCGACGTGGCCGAATATTATGGCTT
GGATCTCTCGTCAGTGGTGCGCGCCGTATTCAAGCAAATGGTGAATACCGGGCGCATCCCATTGACGTTCGCCCCCGAGG
AGCCTAATGGCGAAAGCCTGAACGCCGCTGCCGAAGCGGACAGCTTCATGGCATCGGGCAAGACGGGGCGTTTTACCAAC
GGACACGACCTGCTCGAAGCGGCGATGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C2Z6P7