Detailed information of TA system TA089344

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 816098..816758
• Replicon: chromosome
• Accession: NZ_CP024956
• Organism: Pectobacterium atrosepticum strain 36A

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: Q6D959
• Locus tag: CVS35_RS03845
• Protein ID: WP_011092367.1
• Coordinates: 816345..816758 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: Q6D960
• Locus tag: CVS35_RS03840
• Protein ID: WP_011092366.1
• Coordinates: 816098..816364 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS35_RS03820	811905..812909	-	1005	WP_039296919.1	LacI family transcriptional regulator	-
CVS35_RS03825	812963..813571	-	609	WP_011092363.1	HD domain-containing protein	-
CVS35_RS03830	813990..814637	+	648	WP_039296921.1	hemolysin III family protein	-
CVS35_RS03835	814861..815862	-	1002	WP_011092365.1	tRNA-modifying protein YgfZ	-
CVS35_RS03840	816098..816364	+	267	WP_011092366.1	FAD assembly factor SdhE	Antitoxin
CVS35_RS03845	816345..816758	+	414	WP_011092367.1	protein YgfX	Toxin
CVS35_RS03850	817308..817823	+	516	WP_051122317.1	hypothetical protein	-
CVS35_RS03855	818140..818856	+	717	WP_039309947.1	DUF1311 domain-containing protein	-
CVS35_RS03860	819373..820491	-	1119	WP_039296930.1	hypothetical protein	-
CVS35_RS03865	821011..821625	+	615	WP_039296937.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16397.31 Da
• Isoelectric Point: 10.3509

>T89344 WP_011092367.1 NZ_CP024956:816345-816758 [Pectobacterium atrosepticum]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLALQSINDKERQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Nucleotide

• Length: 414 bp

>T89344 NZ_CP024956:816345-816758 [Pectobacterium atrosepticum]
GTGGCCCAGTGGCAATGTGACCTTCGTGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGCCTACTCGTATT
GCTCATTCTGCTGGCACCGTGGCCGGACGGTTACGCATGGCTATGGCTATGCTTAGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAAAGGAATATCAAATCCCGACAGGGGGAAATCGTTTTGCTTAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTCAAACGACCGTGGCTTTTGAAAAATGGCGTGTTGTTGGCATTGCAATCTATCAACGATAAAGAAAG
ACAACAGCTGTGGCTGGCATCGGACAGTATGGGCGATGATGAGTGGCGCCATCTGCGTCAGCTTCTTTTGCAGCAGAAAC
ACTGGGCGCGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10462.94 Da
• Isoelectric Point: 6.2223

>AT89344 WP_011092366.1 NZ_CP024956:816098-816364 [Pectobacterium atrosepticum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDSDKRAFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT89344 NZ_CP024956:816098-816364 [Pectobacterium atrosepticum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGTGAACTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACAGTGATAAGCGCGCGTTTGTACGCCTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGAAGGACGGAGAGTTGAAACGTATGATTTCCCTTATTCAGACGCGAAAT
AAAGACCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: Q6D959

Antitoxin

• AlphaFold DB: Q6D960