Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 3211957..3212648 Replicon chromosome
Accession NZ_CP024955
Organism Kyrpidia spormannii strain EA-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CVV65_RS15750 Protein ID WP_100668951.1
Coordinates 3212211..3212648 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CVV65_RS15745 Protein ID WP_100668950.1
Coordinates 3211957..3212214 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVV65_RS15710 3207502..3207600 - 99 WP_157935564.1 hypothetical protein -
CVV65_RS15715 3207769..3208035 - 267 WP_100668946.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CVV65_RS15720 3208191..3208769 + 579 WP_100668947.1 IS607 family transposase -
CVV65_RS15725 3208766..3209962 + 1197 WP_133121335.1 IS607 family element transposase accessory protein TnpB -
CVV65_RS15735 3210297..3210842 - 546 WP_133121336.1 helix-turn-helix domain-containing protein -
CVV65_RS15745 3211957..3212214 + 258 WP_100668950.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CVV65_RS15750 3212211..3212648 + 438 WP_100668951.1 type II toxin-antitoxin system VapC family toxin Toxin
CVV65_RS15760 3213640..3214164 - 525 WP_100668952.1 Uma2 family endonuclease -
CVV65_RS15765 3214195..3214404 - 210 WP_198592066.1 hypothetical protein -
CVV65_RS15770 3214778..3216151 - 1374 WP_100669584.1 transposase -
CVV65_RS15775 3216171..3216893 - 723 WP_100668953.1 IS607 family transposase -
CVV65_RS15780 3216952..3217377 - 426 WP_157935565.1 PIN domain-containing protein -
CVV65_RS16845 3217349..3217609 - 261 WP_157935566.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-66)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 16409.90 Da        Isoelectric Point: 7.8282

>T89339 WP_100668951.1 NZ_CP024955:3212211-3212648 [Kyrpidia spormannii]
VKYLLDTCVISELVKRAPAPAVLRWVENQDEENLYLSVLTLGELQRGVSKLLDRSRAEQLQAWLKDDLTQRFQRRILPVD
QKVAVAWGEISGDAARRGETLPVMDSLIAATARVHGLVVVTRNVRDIERCRVPVTNPWPDTRADL

Download         Length: 438 bp

>T89339 NZ_CP024955:3212211-3212648 [Kyrpidia spormannii]
GTGAAATACTTACTGGACACCTGTGTCATTTCTGAACTGGTCAAGAGGGCTCCCGCTCCCGCAGTCCTGAGGTGGGTCGA
GAACCAGGATGAGGAAAACCTGTATTTGAGCGTATTAACCCTGGGAGAACTGCAACGCGGTGTGAGTAAGTTGTTGGATC
GCAGTCGCGCAGAACAATTGCAGGCGTGGTTGAAAGACGACTTAACCCAGCGTTTTCAGAGACGCATCTTGCCCGTCGAC
CAAAAGGTGGCGGTGGCTTGGGGCGAAATCAGTGGAGACGCGGCGCGGCGAGGAGAAACACTCCCTGTCATGGATAGTCT
CATTGCAGCCACCGCCCGGGTTCATGGCCTGGTTGTGGTCACGCGAAACGTACGCGACATAGAACGTTGCCGCGTTCCGG
TTACGAATCCTTGGCCGGACACGCGCGCCGACCTGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9712.25 Da        Isoelectric Point: 9.9218

>AT89339 WP_100668950.1 NZ_CP024955:3211957-3212214 [Kyrpidia spormannii]
MVMDKTWQLQDAKNRLSELVNKAMRNGPQMITVRGKPAVVVVSVQEYERLAHPKASLVEFFRNSPLVGVELDVERVRDHP
RETGL

Download         Length: 258 bp

>AT89339 NZ_CP024955:3211957-3212214 [Kyrpidia spormannii]
ATGGTCATGGACAAGACCTGGCAGCTTCAGGATGCCAAAAATCGCCTCAGTGAACTTGTGAACAAGGCCATGCGGAACGG
TCCGCAGATGATTACGGTGCGCGGGAAACCCGCGGTCGTCGTGGTGTCCGTTCAGGAATATGAGCGTTTAGCACATCCAA
AGGCCAGTCTGGTGGAATTTTTTCGAAATTCCCCTCTGGTCGGGGTTGAACTGGACGTAGAACGAGTCCGGGACCATCCG
CGGGAGACTGGACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References