Detailed information of TA system TA089333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1349550..1350228
• Replicon: chromosome
• Accession: NZ_CP024951
• Organism: Helicobacter pylori B128

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CV725_RS06630
• Protein ID: WP_080006198.1
• Coordinates: 1349550..1349873 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D7FDF9
• Locus tag: CV725_RS06635
• Protein ID: WP_001134161.1
• Coordinates: 1349854..1350228 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV725_RS06610	1346253..1347020	-	768	WP_000242349.1	ABC transporter ATP-binding protein	-
CV725_RS06615	1347020..1348000	-	981	WP_000921449.1	iron ABC transporter permease	-
CV725_RS06620	1347993..1348841	-	849	WP_000504111.1	SDR family oxidoreductase	-
CV725_RS06625	1348981..1349505	+	525	WP_001135637.1	acyl-CoA thioesterase	-
CV725_RS06630	1349550..1349873	-	324	WP_080006198.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
CV725_RS06635	1349854..1350228	-	375	WP_001134161.1	hypothetical protein	Antitoxin
CV725_RS06640	1351253..1353460	-	2208	WP_145801843.1	Hop family adhesin BabA	-
CV725_RS06655	1354387..1354784	-	398	Protein_1254	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12475.74 Da
• Isoelectric Point: 9.5268

>T89333 WP_080006198.1 NZ_CP024951:c1349873-1349550 [Helicobacter pylori B128]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLDPQFQDHALKGKWKPYRECHIKPDILLVYLVKDDELILLRLG
SHSELFCKSPTQFITLKPTAQPTTPLF

Nucleotide

• Length: 324 bp

>T89333 NZ_CP024951:c1349873-1349550 [Helicobacter pylori B128]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGAAGCCTT
ATAGAGAATGCCACATTAAGCCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGGTTAGGC
AGTCATAGCGAGCTGTTTTGTAAATCACCCACACAATTTATAACGCTTAAACCAACCGCTCAACCAACTACCCCCCTTTT
TTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14713.64 Da
• Isoelectric Point: 7.8113

>AT89333 WP_001134161.1 NZ_CP024951:c1350228-1349854 [Helicobacter pylori B128]
MPNTTNKDYTQYSEKQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDVYNKETDLIVEDFSSYSDERKKALGVETQS

Nucleotide

• Length: 375 bp

>AT89333 NZ_CP024951:c1350228-1349854 [Helicobacter pylori B128]
ATGCCAAACACCACCAACAAAGATTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCAAAA
AATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGTGTATAACAAAGAAACAGATTTGATTGTTGAGGATTT
TTCTAGTTACAGCGATGAGAGAAAAAAGGCTTTGGGTGTTGAAACTCAATCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2L2I1T1