Detailed information of TA system TA089332

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 1230466..1231081
• Replicon: chromosome
• Accession: NZ_CP024950
• Organism: Helicobacter pylori strain B130A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CV726_RS06040
• Protein ID: WP_145940514.1
• Coordinates: 1230764..1231081 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I9X093
• Locus tag: CV726_RS06035
• Protein ID: WP_001134035.1
• Coordinates: 1230466..1230777 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV726_RS06020	1226279..1227034	+	756	WP_145940512.1	HugZ family heme oxygenase	-
CV726_RS06025	1227338..1229467	+	2130	WP_145940513.1	Hop family adhesin BabB	-
CV726_RS06035	1230466..1230777	+	312	WP_001134035.1	hypothetical protein	Antitoxin
CV726_RS06040	1230764..1231081	+	318	WP_145940514.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CV726_RS06045	1231447..1232592	+	1146	WP_145940515.1	YbfB/YjiJ family MFS transporter	-
CV726_RS06050	1232598..1233563	-	966	WP_145940516.1	GTP-binding protein	-
CV726_RS06055	1233563..1233940	-	378	WP_145940517.1	hypothetical protein	-
CV726_RS06060	1233986..1234867	-	882	WP_145940518.1	polysaccharide deacetylase	-
CV726_RS06065	1234880..1235758	-	879	WP_145940519.1	carbon-nitrogen hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12139.58 Da
• Isoelectric Point: 10.3941

>T89332 WP_145940514.1 NZ_CP024950:1230764-1231081 [Helicobacter pylori]
MLTIETSKKFDKNLKILIKNGFDLKLLYKVVENLAKEQPLALKYKDHPLKGALKDFRECHLKPDLLLVYQIKKPKNTLFL
VRLGSHSELFYKSPITPKKNATIAC

Nucleotide

• Length: 318 bp

>T89332 NZ_CP024950:1230764-1231081 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGAATCTTAAAATTCTTATTAAAAATGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCTCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGACTTTAGGGAGTGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACCAAAAAACACTCTTTTTTTA
GTAAGACTAGGCAGTCATAGCGAGTTGTTTTATAAATCACCCATAACGCCTAAAAAGAACGCAACAATCGCATGCTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12293.11 Da
• Isoelectric Point: 10.0373

>AT89332 WP_001134035.1 NZ_CP024950:1230466-1230777 [Helicobacter pylori]
MPNTTAEKDYTKYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSIEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT89332 NZ_CP024950:1230466-1230777 [Helicobacter pylori]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A438RJM3