Detailed information of TA system TA089331

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 611850..612420
• Replicon: chromosome
• Accession: NZ_CP024950
• Organism: Helicobacter pylori strain B130A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CV726_RS03040
• Protein ID: WP_145940160.1
• Coordinates: 612148..612420 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I9X093
• Locus tag: CV726_RS03035
• Protein ID: WP_001134035.1
• Coordinates: 611850..612161 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV726_RS02995	607392..608026	-	635	Protein_559	hypothetical protein	-
CV726_RS03020	608630..610861	+	2232	WP_145940022.1	Hop family adhesin BabA	-
CV726_RS03035	611850..612161	+	312	WP_001134035.1	hypothetical protein	Antitoxin
CV726_RS03040	612148..612420	+	273	WP_145940160.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CV726_RS03045	612528..613052	-	525	WP_001135603.1	acyl-CoA thioesterase	-
CV726_RS03050	613192..614046	+	855	WP_145940161.1	SDR family oxidoreductase	-
CV726_RS03055	614039..615019	+	981	WP_000921461.1	iron ABC transporter permease	-
CV726_RS03060	615019..615786	+	768	WP_000242349.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10522.64 Da
• Isoelectric Point: 10.3375

>T89331 WP_145940160.1 NZ_CP024950:612148-612420 [Helicobacter pylori]
MLTIETSKKFDKNLKILIKNGFDLKLLYKVVENLAKEQPLALKYKDHPLKGALKDFRECHLKPDLLLVYQIKKPKNTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T89331 NZ_CP024950:612148-612420 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGAATCTTAAAATTCTTATTAAAAATGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCTCAAATACAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGACTTTAGGGAGTGCCACCTAAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACCAAAAAACACTCTTTTTTTA
GTAAGACTAGGCAGTCATAGCGAGTTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12293.11 Da
• Isoelectric Point: 10.0373

>AT89331 WP_001134035.1 NZ_CP024950:611850-612161 [Helicobacter pylori]
MPNTTAEKDYTKYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSIEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT89331 NZ_CP024950:611850-612161 [Helicobacter pylori]
ATGCCTAACACCACCGCAGAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAGAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGACGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A438RJM3