Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 18497..19664 Replicon chromosome
Accession NZ_CP024950
Organism Helicobacter pylori strain B130A

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag CV726_RS00065 Protein ID WP_145939810.1
Coordinates 18924..19664 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag CV726_RS00060 Protein ID WP_145939809.1
Coordinates 18497..18934 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV726_RS00055 14162..17692 + 3531 WP_145939808.1 class I SAM-dependent DNA methyltransferase -
CV726_RS00060 18497..18934 + 438 WP_145939809.1 SocA family protein Antitoxin
CV726_RS00065 18924..19664 + 741 WP_145939810.1 hypothetical protein Toxin
CV726_RS00070 19880..21067 - 1188 WP_145939811.1 transcription termination/antitermination protein NusA -
CV726_RS00075 21159..22331 - 1173 WP_145939812.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28683.50 Da        Isoelectric Point: 7.1687

>T89330 WP_145939810.1 NZ_CP024950:18924-19664 [Helicobacter pylori]
METKEEDKDKKLEEMIVSLCEKGDLSSQTDQIIKDLKEIYQGEYRHKYSKITTIILNSTRDREQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANACRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFCKKPIFWFNLMVTILLVIGFC
GELHII

Download         Length: 741 bp

>T89330 NZ_CP024950:18924-19664 [Helicobacter pylori]
ATGGAAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAGAAATGATTGTATCTCTGTGCGAAAAGGGGGATTTGTCTAG
CCAAACAGATCAAATCATCAAAGATCTCAAAGAAATCTATCAAGGAGAATACAGGCATAAATACTCAAAAATTACAACTA
TTATTTTAAATTCCACAAGGGATAGAGAGCAAGCCTTTATGACGCTCACACAAAATATAAGGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGACGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTGTCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTGCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATTCTACTTGTGATTGGTTTTTGT
GGAGAATTGCATATAATATAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17379.57 Da        Isoelectric Point: 6.8768

>AT89330 WP_145939809.1 NZ_CP024950:18497-18934 [Helicobacter pylori]
MVNALELAKYILKHSDKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWRYGPIAREVYYEYRNYGANPIDKPKEETL
SQNLRKDELETINRSIEKCNKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIRQEAKQTNGN

Download         Length: 438 bp

>AT89330 NZ_CP024950:18497-18934 [Helicobacter pylori]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCATTCAGACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAGATACG
GGCCTATTGCAAGAGAAGTGTATTACGAATACCGCAATTATGGTGCCAATCCTATTGACAAACCTAAAGAAGAAACGCTC
TCGCAAAATCTTAGAAAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAACAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAGACAAGAAGCCAAACAAACAAATGGAAACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References