Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 261377..261935 Replicon chromosome
Accession NZ_CP024949
Organism Helicobacter pylori strain B136A

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CV727_RS01280 Protein ID WP_145819962.1
Coordinates 261681..261935 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CV727_RS01275 Protein ID WP_145819960.1
Coordinates 261377..261667 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV727_RS01250 256591..257136 + 546 WP_000482429.1 single-stranded DNA-binding protein -
CV727_RS01255 257159..257416 + 258 WP_000440196.1 30S ribosomal protein S18 -
CV727_RS01260 257988..260156 + 2169 WP_145819956.1 Hop family adhesin BabA -
CV727_RS01265 260552..260944 + 393 WP_145819958.1 hypothetical protein -
CV727_RS01270 260925..261209 + 285 WP_000271050.1 endoribonuclease VapD -
CV727_RS01275 261377..261667 + 291 WP_145819960.1 hypothetical protein Antitoxin
CV727_RS01280 261681..261935 + 255 WP_145819962.1 type II toxin-antitoxin system YafQ family toxin Toxin
CV727_RS01285 262056..262580 - 525 WP_001135623.1 acyl-CoA thioesterase -
CV727_RS01290 262739..263581 + 843 WP_145819964.1 SDR family oxidoreductase -
CV727_RS01295 263574..264554 + 981 WP_000921461.1 iron ABC transporter permease -
CV727_RS01300 264554..265321 + 768 WP_000242349.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9691.53 Da        Isoelectric Point: 10.1292

>T89329 WP_145819962.1 NZ_CP024949:261681-261935 [Helicobacter pylori]
MLTIETSKKFDKDLKILVKNGFDLKLLYKVVGNLAKEQPLEPKYKDHPLKGALKDFRECHIKPDVLPVYRVKDNVLTLVR
LGQS

Download         Length: 255 bp

>T89329 NZ_CP024949:261681-261935 [Helicobacter pylori]
ATGCTGACGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
GTATAAAGTGGTTGGAAATTTAGCCAAAGAGCAACCCCTAGAACCCAAATACAAAGACCACCCGCTCAAAGGTGCTTTAA
AAGATTTTAGGGAATGCCACATTAAGCCTGATGTTTTGCCTGTGTATAGAGTGAAAGATAATGTTTTGACTTTAGTCAGG
CTTGGGCAGTCATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11441.24 Da        Isoelectric Point: 10.1922

>AT89329 WP_145819960.1 NZ_CP024949:261377-261667 [Helicobacter pylori]
MPNPTAKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTLEEEREILARAKDTKNH
LCFKSIEDFKKHCENL

Download         Length: 291 bp

>AT89329 NZ_CP024949:261377-261667 [Helicobacter pylori]
ATGCCTAACCCCACCGCCAAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAGGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCACTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCCTAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGATACCAAGAACCAC
CTTTGTTTTAAAAGCATAGAGGATTTTAAAAAACATTGTGAAAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References