Detailed information of TA system TA089327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 25042..26233
• Replicon: chromosome
• Accession: NZ_CP024949
• Organism: Helicobacter pylori strain B136A

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: CV727_RS00085
• Protein ID: WP_145819674.1
• Coordinates: 25469..26233 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: CV727_RS00080
• Protein ID: WP_145819672.1
• Coordinates: 25042..25479 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CV727_RS08240	22990..23142	-	153	WP_161594745.1	hypothetical protein	-
CV727_RS00075	23196..24817	+	1622	Protein_12	RNA-directed DNA polymerase	-
CV727_RS00080	25042..25479	+	438	WP_145819672.1	SocA family protein	Antitoxin
CV727_RS00085	25469..26233	+	765	WP_145819674.1	hypothetical protein	Toxin
CV727_RS00090	26429..27616	-	1188	WP_145819676.1	transcription termination/antitermination protein NusA	-
CV727_RS00095	27718..28878	-	1161	WP_145819678.1	L-seryl-tRNA(Sec) selenium transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29631.78 Da
• Isoelectric Point: 8.5788

>T89327 WP_145819674.1 NZ_CP024949:25469-26233 [Helicobacter pylori]
MGTKEEDKDKKLEKIIVLLCEEGDLSGQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFCKKPMFWFNLIVTILFMIGFV
GELHVIQRLASKYL

Nucleotide

• Length: 765 bp

>T89327 NZ_CP024949:25469-26233 [Helicobacter pylori]
ATGGGAACTAAAGAAGAAGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTGG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAAGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTGCAAAAAACCCATGTTTTGGTTTAATCTAATAGTTACAATTCTATTTATGATTGGTTTTGTG
GGAGAATTGCATGTAATACAAAGATTAGCTTCTAAATATCTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17240.46 Da
• Isoelectric Point: 6.4940

>AT89327 WP_145819672.1 NZ_CP024949:25042-25479 [Helicobacter pylori]
MVNALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANPIDKPKEETL
SQNLREDELETIKCSIEKCNKKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT89327 NZ_CP024949:25042-25479 [Helicobacter pylori]
ATGGTCAATGCTTTGGAGCTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTACGAATATCGCAATTATGGTGCCAATCCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATTAAGTGCTCCATAGAGAAATGCAACAAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCCAAACAAGCAAATGGGAACTAA