Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 552798..553437 Replicon chromosome
Accession NZ_CP024948
Organism Helicobacter pylori strain B140

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag CV728_RS02820 Protein ID WP_145816966.1
Coordinates 553168..553437 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CV728_RS02815 Protein ID WP_145816964.1
Coordinates 552798..553187 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV728_RS02790 548023..549135 + 1113 WP_145816960.1 hydrogenase formation protein HypD -
CV728_RS02795 549086..549729 - 644 Protein_515 hypothetical protein -
CV728_RS02810 550098..552170 + 2073 WP_145816962.1 Hop family adhesin BabB -
CV728_RS02815 552798..553187 + 390 WP_145816964.1 hypothetical protein Antitoxin
CV728_RS02820 553168..553437 + 270 WP_145816966.1 endoribonuclease VapD Toxin
CV728_RS02825 553652..554176 - 525 WP_001135623.1 acyl-CoA thioesterase -
CV728_RS02830 554316..555170 + 855 WP_145816968.1 SDR family oxidoreductase -
CV728_RS02835 555163..556143 + 981 WP_000921461.1 iron ABC transporter permease -
CV728_RS02840 556143..556910 + 768 WP_000242349.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(2-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10599.04 Da        Isoelectric Point: 5.1850

>T89324 WP_145816966.1 NZ_CP024948:553168-553437 [Helicobacter pylori]
VYALAFDLKIEILKKEYKEPYNKAYDDLRQELELLGFENTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFT

Download         Length: 270 bp

>T89324 NZ_CP024948:553168-553437 [Helicobacter pylori]
GTGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACAAAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAAAACACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAAGTAGAGGACTTTAGCGATTTTACTTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 15223.31 Da        Isoelectric Point: 8.6872

>AT89324 WP_145816964.1 NZ_CP024948:552798-553187 [Helicobacter pylori]
MPNTTNKDYTKYSQRQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCLG
RKIPNIQTQQAMRDALNGVNLTQIDSLDDLTNELKRENNKGFESVCFSV

Download         Length: 390 bp

>AT89324 NZ_CP024948:552798-553187 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAACCTTATGAATAAGAAAGAACAAGA
AATTGAAAAGCTAAAAAGGGATAGGGCGTATCTTGAAAAGAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACTTTA
AGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTGGGG
CGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAGTTT
AGATGATCTTACAAACGAGTTAAAAAGAGAAAATAATAAAGGTTTTGAAAGTGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References