Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1124411..1125035 Replicon chromosome
Accession NZ_CP024947
Organism Helicobacter pylori strain J182

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CV729_RS05505 Protein ID WP_145732042.1
Coordinates 1124411..1124677 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CV729_RS05510 Protein ID WP_145732045.1
Coordinates 1124658..1125035 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV729_RS05485 1121077..1121844 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
CV729_RS05490 1121844..1122824 - 981 WP_000921458.1 iron ABC transporter permease -
CV729_RS05495 1122817..1123665 - 849 WP_145732886.1 SDR family oxidoreductase -
CV729_RS05500 1123805..1124329 + 525 WP_001135603.1 acyl-CoA thioesterase -
CV729_RS05505 1124411..1124677 - 267 WP_145732042.1 type II toxin-antitoxin system YafQ family toxin Toxin
CV729_RS05510 1124658..1125035 - 378 WP_145732045.1 hypothetical protein Antitoxin
CV729_RS05515 1125505..1127634 - 2130 WP_145732888.1 Hop family adhesin BabB -
CV729_RS05530 1127968..1128602 + 635 Protein_1046 hypothetical protein -
CV729_RS05535 1128553..1129665 - 1113 WP_145732890.1 hydrogenase formation protein HypD -
CV729_RS05540 1129692..1129928 - 237 WP_000335442.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10283.22 Da        Isoelectric Point: 9.6292

>T89323 WP_145732042.1 NZ_CP024947:c1124677-1124411 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLPPPFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T89323 NZ_CP024947:c1124677-1124411 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTACCCCCACCATTTAAAGATCATGCCTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14724.84 Da        Isoelectric Point: 9.8461

>AT89323 WP_145732045.1 NZ_CP024947:c1125035-1124658 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLINQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNIQTQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQS

Download         Length: 378 bp

>AT89323 NZ_CP024947:c1125035-1124658 [Helicobacter pylori]
ATGCCAAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCAACCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References