Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 535380..536118 Replicon chromosome
Accession NZ_CP024947
Organism Helicobacter pylori strain J182

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CV729_RS02645 Protein ID WP_145732042.1
Coordinates 535852..536118 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CV729_RS02640 Protein ID WP_145733514.1
Coordinates 535380..535772 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV729_RS02610 530912..532030 - 1119 WP_145732031.1 site-specific DNA-methyltransferase -
CV729_RS02615 532125..532493 + 369 WP_145732033.1 hypothetical protein -
CV729_RS02620 532493..533458 + 966 WP_145732035.1 GTP-binding protein -
CV729_RS02625 533464..534609 - 1146 WP_145732037.1 YbfB/YjiJ family MFS transporter -
CV729_RS02635 535115..535399 - 285 WP_145732040.1 endoribonuclease VapD -
CV729_RS02640 535380..535772 - 393 WP_145733514.1 hypothetical protein Antitoxin
CV729_RS02645 535852..536118 - 267 WP_145732042.1 type II toxin-antitoxin system YafQ family toxin Toxin
CV729_RS02650 536099..536476 - 378 WP_145732045.1 hypothetical protein -
CV729_RS02655 536995..539229 - 2235 WP_145732046.1 Hop family adhesin BabA -
CV729_RS02660 539518..540273 - 756 WP_145732048.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10283.22 Da        Isoelectric Point: 9.6292

>T89321 WP_145732042.1 NZ_CP024947:c536118-535852 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLPPPFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T89321 NZ_CP024947:c536118-535852 [Helicobacter pylori]
GTGTTAAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCACTACCCCCACCATTTAAAGATCATGCCTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTAGTGAAAGATGATGAACTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15203.32 Da        Isoelectric Point: 9.1381

>AT89321 WP_145733514.1 NZ_CP024947:c535772-535380 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLINQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNIQTQQAMRDALNGVNLTQIDSLDDLTNELKRENNKGFENVCSSV

Download         Length: 393 bp

>AT89321 NZ_CP024947:c535772-535380 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCAACCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAATAAAGGTTTTGAAAATGTATGCTCTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References