Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 535115..535772 Replicon chromosome
Accession NZ_CP024947
Organism Helicobacter pylori strain J182

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag CV729_RS02635 Protein ID WP_145732040.1
Coordinates 535115..535399 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CV729_RS02640 Protein ID WP_145733514.1
Coordinates 535380..535772 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV729_RS02605 530218..530910 - 693 WP_108169276.1 restriction endonuclease -
CV729_RS02610 530912..532030 - 1119 WP_145732031.1 site-specific DNA-methyltransferase -
CV729_RS02615 532125..532493 + 369 WP_145732033.1 hypothetical protein -
CV729_RS02620 532493..533458 + 966 WP_145732035.1 GTP-binding protein -
CV729_RS02625 533464..534609 - 1146 WP_145732037.1 YbfB/YjiJ family MFS transporter -
CV729_RS02635 535115..535399 - 285 WP_145732040.1 endoribonuclease VapD Toxin
CV729_RS02640 535380..535772 - 393 WP_145733514.1 hypothetical protein Antitoxin
CV729_RS02645 535852..536118 - 267 WP_145732042.1 type II toxin-antitoxin system YafQ family toxin -
CV729_RS02650 536099..536476 - 378 WP_145732045.1 hypothetical protein -
CV729_RS02655 536995..539229 - 2235 WP_145732046.1 Hop family adhesin BabA -
CV729_RS02660 539518..540273 - 756 WP_145732048.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11215.77 Da        Isoelectric Point: 5.2187

>T89320 WP_145732040.1 NZ_CP024947:c535399-535115 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFENTQRSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T89320 NZ_CP024947:c535399-535115 [Helicobacter pylori]
ATGTATGCTCTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAAAACACTCAAAGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTAGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15203.32 Da        Isoelectric Point: 9.1381

>AT89320 WP_145733514.1 NZ_CP024947:c535772-535380 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLINQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNIQTQQAMRDALNGVNLTQIDSLDDLTNELKRENNKGFENVCSSV

Download         Length: 393 bp

>AT89320 NZ_CP024947:c535772-535380 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCAACCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGCTGTTTG
GGGCGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGTTAAATGGGGTTAATCTCACTCAAATTGATAG
TTTAGATGATCTTACAAACGAGTTAAAAAGAGAAAATAATAAAGGTTTTGAAAATGTATGCTCTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References