Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1104473..1105091 Replicon chromosome
Accession NZ_CP024946
Organism Helicobacter pylori strain B147

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CV730_RS05325 Protein ID WP_145728669.1
Coordinates 1104473..1104733 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CV730_RS05330 Protein ID WP_145728670.1
Coordinates 1104714..1105091 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CV730_RS05305 1101146..1101913 - 768 WP_145728666.1 ABC transporter ATP-binding protein -
CV730_RS05310 1101913..1102893 - 981 WP_145728667.1 iron ABC transporter permease -
CV730_RS05315 1102886..1103734 - 849 WP_145728668.1 SDR family oxidoreductase -
CV730_RS05320 1103874..1104397 + 524 Protein_1010 acyl-CoA thioesterase -
CV730_RS05325 1104473..1104733 - 261 WP_145728669.1 type II toxin-antitoxin system YafQ family toxin Toxin
CV730_RS05330 1104714..1105091 - 378 WP_145728670.1 hypothetical protein Antitoxin
CV730_RS05340 1105396..1107582 - 2187 WP_145728671.1 outer membrane beta-barrel protein -
CV730_RS05355 1107944..1108587 + 644 Protein_1014 hypothetical protein -
CV730_RS05360 1108538..1109650 - 1113 WP_145728672.1 hydrogenase formation protein HypD -
CV730_RS05365 1109656..1109892 - 237 WP_000335478.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10083.95 Da        Isoelectric Point: 8.5359

>T89318 WP_145728669.1 NZ_CP024946:c1104733-1104473 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILRKKEPLDPQFQDHALKGKWKPFRECHIKPDVLLVCLVKDDELILLRLG
SHSELF

Download         Length: 261 bp

>T89318 NZ_CP024946:c1104733-1104473 [Helicobacter pylori]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAAAGAGGTCATTCTAAGAAAGAAAGAACCGCTAGATCCACAATTTCAAGATCATGCCCTAAAAGGCAAGTGGAAACCTT
TTAGGGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTGTCTAGTGAAAGATGATGAGCTGATTTTGTTAAGACTAGGC
AGTCATAGCGAGTTGTTTTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14673.80 Da        Isoelectric Point: 9.8465

>AT89318 WP_145728670.1 NZ_CP024946:c1105091-1104714 [Helicobacter pylori]
MPNTTTKKDYTKYSEKQLFNLIHQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIGALNELLQKISQAFDDKRDCCL
GRKIPNIQTQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQP

Download         Length: 378 bp

>AT89318 NZ_CP024946:c1105091-1104714 [Helicobacter pylori]
ATGCCTAACACCACCACCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAACTTAATCCATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGGCGCGTTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References