Detailed information of TA system TA089317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3525635..3526281
• Replicon: chromosome
• Accession: NZ_CP024944
• Organism: Burkholderia lata strain A05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CVS37_RS35620
• Protein ID: WP_122949353.1
• Coordinates: 3525874..3526281 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A3G3HIS6
• Locus tag: CVS37_RS35615
• Protein ID: WP_043179333.1
• Coordinates: 3525635..3525877 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS37_RS35600	3521650..3523056	+	1407	WP_122949350.1	aspartate ammonia-lyase	-
CVS37_RS35605	3523164..3524675	+	1512	WP_122949351.1	amino acid permease	-
CVS37_RS35610	3524737..3525420	-	684	WP_122949352.1	phospholipase	-
CVS37_RS35615	3525635..3525877	+	243	WP_043179333.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CVS37_RS35620	3525874..3526281	+	408	WP_122949353.1	type II toxin-antitoxin system VapC family toxin	Toxin
CVS37_RS35625	3526340..3527827	-	1488	WP_122949354.1	aldehyde dehydrogenase	-
CVS37_RS35630	3527856..3528434	-	579	WP_122949355.1	thioesterase family protein	-
CVS37_RS35635	3528708..3529838	+	1131	WP_122949356.1	porin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14912.08 Da
• Isoelectric Point: 6.2320

>T89317 WP_122949353.1 NZ_CP024944:3525874-3526281 [Burkholderia lata]
MKFLLDTNAVIAIMKGEPAMLARLRTYQPADFGMPAIVAHELYYGAYKSQRAAANVARVEALQFEVVSFDAEDAQHAGAI
RAQLTAAGTPIGPYDALIAGQARARRLVLVTHNMREFSRVPELQVEDWLAEPREN

Nucleotide

• Length: 408 bp

>T89317 NZ_CP024944:3525874-3526281 [Burkholderia lata]
ATGAAATTTCTGCTGGATACCAACGCGGTAATCGCCATCATGAAAGGCGAGCCGGCCATGCTGGCCCGGCTGCGCACGTA
TCAGCCAGCGGATTTCGGCATGCCGGCGATCGTCGCACATGAGCTCTATTACGGCGCATACAAGAGCCAGAGAGCGGCAG
CGAACGTAGCGCGTGTCGAGGCACTTCAGTTCGAGGTGGTGTCGTTCGATGCGGAAGATGCCCAGCATGCCGGAGCGATT
CGTGCGCAACTGACCGCGGCTGGAACCCCGATCGGTCCGTACGATGCGCTGATTGCAGGGCAGGCGCGCGCCCGGCGTCT
GGTGCTTGTCACGCATAACATGCGCGAGTTTTCACGAGTCCCGGAGCTACAGGTCGAGGATTGGCTCGCCGAGCCGCGTG
AAAACTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8886.00 Da
• Isoelectric Point: 4.7628

>AT89317 WP_043179333.1 NZ_CP024944:3525635-3525877 [Burkholderia lata]
VDTAKIFKHGGSQAVRLPKDFRFETTEVRIRRHGSSVILEPVPQDWAWLTPLIGPVDADFEAAATTEPAAQERPGLDVFE

Nucleotide

• Length: 243 bp

>AT89317 NZ_CP024944:3525635-3525877 [Burkholderia lata]
GTGGATACTGCCAAGATTTTCAAGCATGGCGGATCGCAGGCTGTCCGTCTGCCGAAGGATTTCCGCTTCGAAACGACCGA
GGTACGGATTCGTCGCCACGGGTCATCCGTCATTCTCGAACCGGTGCCGCAAGACTGGGCATGGCTCACGCCGCTGATCG
GCCCGGTCGACGCCGATTTCGAGGCTGCCGCAACGACCGAGCCTGCCGCTCAGGAGCGCCCGGGTCTGGACGTATTTGAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A3G3HIS6