Detailed information of TA system TA089314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1789690..1790255
• Replicon: chromosome
• Accession: NZ_CP024944
• Organism: Burkholderia lata strain A05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CVS37_RS27365
• Protein ID: WP_122948072.1
• Coordinates: 1789884..1790255 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A228INJ9
• Locus tag: CVS37_RS27360
• Protein ID: WP_069252544.1
• Coordinates: 1789690..1789887 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS37_RS27335	1784812..1785267	-	456	WP_069252540.1	RbsD/FucU family protein	-
CVS37_RS27340	1785347..1785757	-	411	WP_122948069.1	nuclear transport factor 2 family protein	-
CVS37_RS27345	1786044..1787597	-	1554	WP_043180866.1	galactarate dehydratase	-
CVS37_RS27350	1787827..1788741	+	915	WP_122948070.1	5-dehydro-4-deoxyglucarate dehydratase	-
CVS37_RS27355	1788856..1789410	-	555	WP_122948071.1	hypothetical protein	-
CVS37_RS27360	1789690..1789887	+	198	WP_069252544.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
CVS37_RS27365	1789884..1790255	+	372	WP_122948072.1	type II toxin-antitoxin system VapC family toxin	Toxin
CVS37_RS27370	1790402..1791979	-	1578	WP_122948073.1	aldehyde dehydrogenase (NADP(+))	-
CVS37_RS27375	1792221..1793606	+	1386	WP_164462733.1	MFS transporter	-
CVS37_RS27380	1793678..1794403	-	726	WP_043180875.1	site-2 protease family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-108)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13418.43 Da
• Isoelectric Point: 5.4683

>T89314 WP_122948072.1 NZ_CP024944:1789884-1790255 [Burkholderia lata]
MILVDTSVWIDHLRAGDVTLTTLLETERVLIHPFVIGELALGSLRDRQTVLDALRDLPVATSATDDEVQQMVDVVPLHGL
GIGYVDAHLLASVRLTDGSKLWTRDRRLLGAADRLGLAAHPAH

Nucleotide

• Length: 372 bp

>T89314 NZ_CP024944:1789884-1790255 [Burkholderia lata]
ATGATTCTTGTCGACACCTCCGTCTGGATCGACCATCTTCGAGCCGGCGACGTCACGCTCACCACGCTACTGGAAACCGA
ACGCGTACTGATCCATCCTTTCGTCATCGGCGAACTCGCCCTCGGCAGCCTGCGAGATCGCCAGACCGTGCTGGATGCGC
TGCGCGACCTACCCGTCGCCACGTCCGCAACCGACGACGAAGTTCAGCAAATGGTCGATGTCGTGCCGCTTCACGGGCTC
GGCATCGGCTACGTCGATGCGCACCTGCTCGCGTCGGTCCGACTGACCGATGGAAGCAAACTGTGGACACGCGACCGGCG
CCTACTGGGTGCAGCAGACCGCCTGGGGCTCGCCGCGCATCCCGCCCACTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7040.11 Da
• Isoelectric Point: 10.4525

>AT89314 WP_069252544.1 NZ_CP024944:1789690-1789887 [Burkholderia lata]
MRTTLSLDDALLAKAQQLTGVTEKSALVKEALRALIARESARRLARLGGTEPDLESIPRRPSEPA

Nucleotide

• Length: 198 bp

>AT89314 NZ_CP024944:1789690-1789887 [Burkholderia lata]
ATGCGCACTACCTTGTCCCTTGACGACGCCCTGCTCGCCAAAGCGCAGCAATTAACTGGCGTGACCGAAAAATCGGCCTT
GGTGAAAGAAGCGCTGCGCGCGTTGATCGCCCGCGAAAGCGCCCGGCGGCTCGCCCGTCTCGGTGGCACCGAACCTGATC
TCGAATCCATCCCGCGCCGCCCGTCGGAGCCAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A228INJ9