Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1114103..1114758 Replicon chromosome
Accession NZ_CP024944
Organism Burkholderia lata strain A05

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CVS37_RS24295 Protein ID WP_122947611.1
Coordinates 1114103..1114522 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CVS37_RS24300 Protein ID WP_122947612.1
Coordinates 1114519..1114758 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS37_RS24270 1109511..1110305 + 795 WP_043179886.1 AraC family transcriptional regulator -
CVS37_RS24275 1110512..1111471 + 960 WP_122949573.1 DMT family transporter -
CVS37_RS24280 1111657..1112229 + 573 WP_122947609.1 permease -
CVS37_RS24285 1112325..1112459 - 135 WP_009688930.1 entericidin A/B family lipoprotein -
CVS37_RS24290 1112693..1113988 + 1296 WP_122947610.1 aspartate carbamoyltransferase -
CVS37_RS24295 1114103..1114522 - 420 WP_122947611.1 type II toxin-antitoxin system VapC family toxin Toxin
CVS37_RS24300 1114519..1114758 - 240 WP_122947612.1 Arc family DNA-binding protein Antitoxin
CVS37_RS24305 1115080..1117323 + 2244 WP_122947613.1 TonB-dependent siderophore receptor -
CVS37_RS24310 1117327..1118100 + 774 WP_122947614.1 sel1 repeat family protein -
CVS37_RS24315 1118097..1118780 + 684 WP_122947615.1 Fe2+-dependent dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15081.41 Da        Isoelectric Point: 7.0177

>T89313 WP_122947611.1 NZ_CP024944:c1114522-1114103 [Burkholderia lata]
MILVDTNVMSEPLRREPSAAVIEWLDAQNVETLFLAAISLGEMRFGVAALPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYAGIRARARASGSAIAPADVFIAATAEANGLIIATRDVAPFKAVGLRVIDPWAS

Download         Length: 420 bp

>T89313 NZ_CP024944:c1114522-1114103 [Burkholderia lata]
ATGATTCTTGTTGATACGAACGTGATGTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAATGGCTCGATGC
CCAGAACGTCGAAACGTTGTTTCTGGCTGCGATCAGTCTCGGCGAAATGCGCTTCGGCGTGGCGGCACTGCCTGAAGGGC
GCAGGCGCGACTGGCTTCACCAAAGCATCGAGCAGCGCGTGGTGCCGCTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCGGCGAGCAAAGCGTATGCGGGTATTCGAGCGCGTGCGCGTGCGTCAGGCAGCGCGATCGCACCAGCGGATGTCTTTAT
CGCCGCGACGGCCGAGGCGAACGGGTTGATCATTGCGACGCGCGACGTCGCGCCATTCAAGGCGGTCGGCTTGCGGGTGA
TCGATCCGTGGGCGTCCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8748.00 Da        Isoelectric Point: 5.6939

>AT89313 WP_122947612.1 NZ_CP024944:c1114758-1114519 [Burkholderia lata]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVEFDVQRDKTLTDPMSFE

Download         Length: 240 bp

>AT89313 NZ_CP024944:c1114758-1114519 [Burkholderia lata]
ATGCCTGTGATTACCGTTCGAAATTTGCCCGATGAAGTGCACCGCGCGCTCCGAATTCGCGCGGCCCAGCATGGGCGTAG
CACCGAAGCCGAGGTACGTGACATCCTTGAGCAGGCCGTTCTGCCGGGTGGCCGGCTGAAGCTCGGGACGCTGCTGGCGG
AAATCGGACGGGAGGCGGGCGGCGTCGAATTCGACGTTCAGCGCGACAAGACGCTAACCGACCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References