Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 888644..890394 Replicon chromosome
Accession NZ_CP024944
Organism Burkholderia lata strain A05

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CVS37_RS23195 Protein ID WP_122947449.1
Coordinates 889498..890394 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CVS37_RS23190 Protein ID WP_122947448.1
Coordinates 888644..889501 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS37_RS23170 883819..885309 - 1491 WP_122947444.1 aldehyde dehydrogenase -
CVS37_RS23175 885382..886197 - 816 WP_122947445.1 aspartate dehydrogenase -
CVS37_RS23180 886190..887857 - 1668 WP_122947446.1 thiamine pyrophosphate-binding protein -
CVS37_RS23185 887850..888647 - 798 WP_122947447.1 SDR family oxidoreductase -
CVS37_RS23190 888644..889501 - 858 WP_122947448.1 IclR family transcriptional regulator Antitoxin
CVS37_RS23195 889498..890394 - 897 WP_122947449.1 alpha/beta fold hydrolase Toxin
CVS37_RS23200 890413..890940 - 528 WP_043177345.1 cupin domain-containing protein -
CVS37_RS23205 890978..891748 - 771 WP_122947450.1 SDR family oxidoreductase -
CVS37_RS23210 891741..892817 - 1077 WP_089452518.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CVS37_RS23215 892870..893181 - 312 WP_122947451.1 hypothetical protein -
CVS37_RS23220 893183..893500 - 318 WP_006758060.1 non-heme iron oxygenase ferredoxin subunit -
CVS37_RS23225 893945..895024 + 1080 WP_122947452.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30762.97 Da        Isoelectric Point: 7.7327

>T89312 WP_122947449.1 NZ_CP024944:c890394-889498 [Burkholderia lata]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLDELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

>T89312 NZ_CP024944:c890394-889498 [Burkholderia lata]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGCGGCCGGCGCAGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCAGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGTTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTAGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTATGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAATGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGCGGCCTCGCCC
GCGTGATGCCTGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGTAGCGCACCGGCCGAAACACGC
GAATCGCGCCGCGACGCGCGGCTCGCGATGCTTGACGAACTCGGCCCGGCCGGGCTTGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCAACGGATCTCGCCGGCTTTCGCGGCCGTACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCAGGCCATGCCGGCTACGTGGAAGCACCGGCCGTTTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGACTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31337.81 Da        Isoelectric Point: 6.5058

>AT89312 WP_122947448.1 NZ_CP024944:c889501-888644 [Burkholderia lata]
MNEPLQQPDSENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT89312 NZ_CP024944:c889501-888644 [Burkholderia lata]
ATGAACGAACCGCTGCAACAACCCGATTCCGAAAACGGCAAGGCCGAAGCGAGCTACGTGGTACCCGGCCTCGAACGCGG
GCTGCGGATTCTCGCTGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCGGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGGAACTACAAG
CTTGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTGGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGTGATGTGGTGTTCGTCGCGAAGGCGC
AAAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGCTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGTTGAAGGAACTGCATGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGTGCGAC
GCCGGAAACGGTCGATGCGCTGTATGAAGTGATCCGCGAGGATGCGCTGCGCGGTTACGGCGTCAGCAACTCGTCGTTCG
AGCGCGGCATCTCGGTCGTGACGGCGCCGGTGCGCAACGAGACGCAGAGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCGGAGATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References