89311

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 120495..121534 Replicon chromosome
Accession NZ_CP024944
Organism Burkholderia lata strain A05

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CVS37_RS19775 Protein ID WP_122946881.1
Coordinates 120959..121534 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CVS37_RS19770 Protein ID WP_122949500.1
Coordinates 120495..120962 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS37_RS19745 115840..117303 + 1464 WP_122946876.1 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase -
CVS37_RS19750 117464..118312 + 849 WP_122946877.1 3,4-dihydroxyphenylacetate 2,3-dioxygenase -
CVS37_RS19755 118346..118738 + 393 WP_122946878.1 5-carboxymethyl-2-hydroxymuconate Delta-isomerase -
CVS37_RS19760 118759..119562 + 804 WP_122946879.1 2-oxo-hepta-3-ene-1,7-dioic acid hydratase -
CVS37_RS19765 119575..120381 + 807 WP_122946880.1 4-hydroxy-2-oxoheptanedioate aldolase -
CVS37_RS19770 120495..120962 + 468 WP_122949500.1 helix-turn-helix domain-containing protein Antitoxin
CVS37_RS19775 120959..121534 + 576 WP_122946881.1 PIN domain-containing protein Toxin
CVS37_RS19780 121585..122382 - 798 WP_122946882.1 helix-turn-helix transcriptional regulator -
CVS37_RS19785 122478..122729 + 252 WP_122946883.1 hypothetical protein -
CVS37_RS19790 122776..123741 + 966 WP_122946884.1 zinc-binding alcohol dehydrogenase family protein -
CVS37_RS19795 123991..125082 - 1092 WP_122946885.1 porin -
CVS37_RS19800 125250..126317 - 1068 WP_122946886.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21595.59 Da        Isoelectric Point: 5.6706

>T89311 WP_122946881.1 NZ_CP024944:120959-121534 [Burkholderia lata]
MTSSPFTAVYDASVLYPAPLRDFLMRLALSGCFRARWSAHIHNEWKRNLLRNRPDLSAEQLDRTSCLMDRAIPDAVVTGY
ESLIDGLALPDADDRHVLAAAIRCNASVIVTFNQKDFPDERLSQYGVEAQHPDEFVDNLFDLEPAAVVAAARRQRETLKY
PPVTADRYLEILQRQGMVQTCKALEAYRAIL

Download         Length: 576 bp

>T89311 NZ_CP024944:120959-121534 [Burkholderia lata]
ATGACGAGTTCGCCGTTCACGGCCGTCTATGATGCCAGTGTGCTTTATCCCGCGCCGCTTCGCGATTTTCTGATGCGGCT
TGCGTTGAGTGGATGCTTCCGCGCTCGCTGGAGCGCGCATATTCACAACGAGTGGAAGCGTAACCTGCTGCGCAATCGCC
CCGACTTGAGCGCCGAGCAGCTTGATCGGACGTCGTGTCTGATGGATCGGGCAATACCCGATGCTGTTGTGACCGGATAT
GAATCGCTGATCGATGGGCTTGCGCTTCCTGATGCCGATGATCGTCACGTACTTGCGGCTGCAATCCGTTGCAACGCTAG
TGTGATCGTAACGTTCAATCAGAAAGATTTCCCGGATGAGAGGCTGTCGCAGTACGGCGTCGAGGCCCAGCACCCCGACG
AGTTCGTCGATAATCTTTTCGATCTTGAGCCTGCGGCGGTCGTTGCGGCTGCGCGGCGACAACGAGAAACGCTCAAGTAT
CCGCCAGTGACCGCAGATCGATATCTGGAGATCCTGCAACGTCAAGGCATGGTCCAGACGTGCAAAGCACTCGAAGCCTA
CCGGGCAATTCTTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17505.83 Da        Isoelectric Point: 5.8659

>AT89311 WP_122949500.1 NZ_CP024944:120495-120962 [Burkholderia lata]
MPHTTTPDVILPVEREMQAAVEGQRTLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMHYKAERDQASADAMDELSKQAQELRMGYE

Download         Length: 468 bp

>AT89311 NZ_CP024944:120495-120962 [Burkholderia lata]
ATGCCCCATACCACGACACCCGACGTGATCTTGCCTGTCGAGCGCGAGATGCAGGCGGCTGTCGAAGGGCAGCGCACGTT
GGCGGCGTATCTCGCAACGCGAACCGATACGCAGCGCATTCAGATCTTTGACGACGAGAATCGCGCGCATCAGGTTGAGC
TCCCGACGTCGGCACTTCGGCTGTTGGTAGATATTCTCGCGGAGCTGGCCGACGGCAACGCGGTCAAGGTCGTACCGGTT
CACGCGGAATTGACGACTCAAGAAGCGGCAGATTTGCTCAATGTTTCTCGCCCGCACCTGATCAAGCTGCTTGAATCGAA
TGCGTTGCCGTATCACCGGACGGGCAAGCATCGGCGTGTGCGTTTTTCCGATCTGATGCATTACAAGGCAGAGCGCGATC
AGGCGAGTGCCGACGCAATGGATGAGTTGAGCAAGCAGGCTCAGGAGTTGCGGATGGGCTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References