Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2063446..2064122 Replicon chromosome
Accession NZ_CP024943
Organism Burkholderia lata strain A05

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag CVS37_RS10085 Protein ID WP_089456196.1
Coordinates 2063706..2064122 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag CVS37_RS10080 Protein ID WP_122946671.1
Coordinates 2063446..2063709 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CVS37_RS10065 2059002..2061254 + 2253 WP_122945329.1 TonB-dependent siderophore receptor -
CVS37_RS10070 2061341..2062180 + 840 WP_122946670.1 N(5)-hydroxyornithine transformylase PvdF -
CVS37_RS10075 2062180..2063196 + 1017 WP_122945330.1 acetyltransferase -
CVS37_RS10080 2063446..2063709 + 264 WP_122946671.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CVS37_RS10085 2063706..2064122 + 417 WP_089456196.1 PIN domain-containing protein Toxin
CVS37_RS10090 2064171..2065076 - 906 WP_122945331.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
CVS37_RS10095 2065045..2066115 - 1071 WP_122945332.1 hypothetical protein -
CVS37_RS10100 2066457..2067620 + 1164 WP_122945333.1 amidohydrolase -
CVS37_RS10105 2067808..2068347 + 540 WP_122946672.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14589.72 Da        Isoelectric Point: 7.9142

>T89310 WP_089456196.1 NZ_CP024943:2063706-2064122 [Burkholderia lata]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTHNSREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T89310 NZ_CP024943:2063706-2064122 [Burkholderia lata]
GTGACGACGCTCTACATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCGCGGTT
GCAATCGTGCGTCAATGCGCAACACCGGATCGTCGTCTCGGCAATTACGTATGCCGAAATGCGGTTCGGTGCGGTTGGCA
GGAAGGCGTCGCCAAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGGCTGGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGTGCCGATCTCGCGGCGCGCGGCACACCGATCGGCGCGAACGACGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGTGCGGTGCTCGTCACGCACAACAGCCGCGAGTTCGGCCGTGTCGCCGGGTTGTCACTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9718.99 Da        Isoelectric Point: 4.6310

>AT89310 WP_122946671.1 NZ_CP024943:2063446-2063709 [Burkholderia lata]
MRTVSIFKNARNQAIRIPKDMEFKGVTELEIRREGDTLLLRPVRPTWLSFGSEPLADADFLAERPAIIESGRFDLSDDGA
APTESGQ

Download         Length: 264 bp

>AT89310 NZ_CP024943:2063446-2063709 [Burkholderia lata]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCGATCCGCATCCCGAAGGACATGGAGTTCAAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGCTGCTGCTGCGGCCGGTGCGGCCCACGTGGCTCTCGTTCGGGAGCGAAC
CGCTGGCCGACGCCGACTTCCTCGCCGAACGCCCGGCCATCATCGAGTCCGGCCGCTTCGATCTGTCCGATGATGGCGCT
GCGCCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References