Detailed information of TA system TA089309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 193826..194463
• Replicon: chromosome
• Accession: NZ_CP024943
• Organism: Burkholderia lata strain A05

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CVS37_RS00890
• Protein ID: WP_122944106.1
• Coordinates: 194062..194463 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: CVS37_RS00885
• Protein ID: WP_122944105.1
• Coordinates: 193826..194062 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CVS37_RS00865	189251..190285	+	1035	WP_122944102.1	helix-turn-helix domain-containing protein	-
CVS37_RS00875	190667..191764	-	1098	WP_122944103.1	ADP-heptose--LPS heptosyltransferase	-
CVS37_RS00880	191761..193464	-	1704	WP_122944104.1	thiamine pyrophosphate-binding protein	-
CVS37_RS00885	193826..194062	+	237	WP_122944105.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CVS37_RS00890	194062..194463	+	402	WP_122944106.1	type II toxin-antitoxin system VapC family toxin	Toxin
CVS37_RS00895	194530..195918	-	1389	WP_122944107.1	L-serine ammonia-lyase	-
CVS37_RS00900	195949..197085	-	1137	WP_122946577.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14956.99 Da
• Isoelectric Point: 4.5976

>T89309 WP_122944106.1 NZ_CP024943:194062-194463 [Burkholderia lata]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTTCASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFDSYPGLRLENWLDD

Nucleotide

• Length: 402 bp

>T89309 NZ_CP024943:194062-194463 [Burkholderia lata]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTACCTGATGAAGAATCAGCCGGAGCAGGTTGCGAGACGATTTGC
GCAGTGCTACACGGGGGACGTCGTGATGTCGGCGATCACGTACGCAGAGCTCGAGTACGGCGTCACGACGTGCGCGAGCC
CTGCGCGGGAGCGCGGCAATCTTGCCGCGCTGATCGACGACATTCCGGTCGCGCCGTTCGACGTCGCGGCTGCGCAAGCG
TACGGCCCGGTCCGCGAGGCAACCCGCGAGCGGAAGAAGGATCACCTCGACAAGCTGATCGCCGCTCATGCGGTGTCGCT
CGATGTTGTCCTCGTGACCAACAACGAGCGGGATTTCGACAGTTATCCGGGATTGCGGCTGGAGAACTGGCTGGACGATT
GA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9036.14 Da
• Isoelectric Point: 5.7316

>AT89309 WP_122944105.1 NZ_CP024943:193826-194062 [Burkholderia lata]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAQFGPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT89309 NZ_CP024943:193826-194062 [Burkholderia lata]
ATGCATACGACGAGGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTGGCCTATGAACGCAGTGA
TATCGAACTGGAAATCGAGCGCATCGGCGACGAAATCCGTATTCGGCCGGCGCGGCGGCCGTTGACCCGCGTCCTCGAGA
AATTCGCGCAATTCGGGCCGGATTTCATGGCTGAAGGGCGTGGTGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA