Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1098695..1100494 Replicon chromosome
Accession NZ_CP024942
Organism Paraburkholderia terricola strain mHS1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CUJ90_RS23510 Protein ID WP_114164037.1
Coordinates 1099604..1100494 (-) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CUJ90_RS23505 Protein ID WP_083083022.1
Coordinates 1098695..1099546 (-) Length 284 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ90_RS23485 1093904..1095394 - 1491 WP_114164034.1 aldehyde dehydrogenase -
CUJ90_RS23490 1095427..1096257 - 831 WP_114164035.1 aspartate dehydrogenase -
CUJ90_RS23495 1096250..1097908 - 1659 WP_114164684.1 thiamine pyrophosphate-binding protein -
CUJ90_RS23500 1097901..1098698 - 798 WP_114164036.1 SDR family oxidoreductase -
CUJ90_RS23505 1098695..1099546 - 852 WP_083083022.1 IclR family transcriptional regulator Antitoxin
CUJ90_RS23510 1099604..1100494 - 891 WP_114164037.1 alpha/beta hydrolase Toxin
CUJ90_RS23515 1100533..1101060 - 528 WP_073429682.1 cupin domain-containing protein -
CUJ90_RS23520 1101087..1101854 - 768 WP_114164038.1 SDR family oxidoreductase -
CUJ90_RS23525 1101847..1102938 - 1092 WP_114164039.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CUJ90_RS23530 1102987..1103298 - 312 WP_073429679.1 hypothetical protein -
CUJ90_RS23535 1103300..1103614 - 315 WP_073429678.1 non-heme iron oxygenase ferredoxin subunit -
CUJ90_RS23540 1104054..1105127 + 1074 WP_114164040.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, C-terminal

(136-260)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30994.17 Da        Isoelectric Point: 7.3493

>T89307 WP_114164037.1 NZ_CP024942:c1100494-1099604 [Paraburkholderia terricola]
MSAVPSATADQNATLEARLARFPAQQIWLASQRAVSYREANSAATNALPLVLLHGIGSGAASWVQQFETLGDTRRVIAWD
APGYGASTPVTPESPAAADYAAVLNEWLDALAIERCVLLGHSLGAIIAGAFAMTYPRRVAGLLLLSPAGGYGAASAAVRE
TKRAQRLAMLEALGPQGLAEKRSAAMLSAYASDEARAWVRWNMSRVIPHGYAQATHLLANADLAADLVRYSGRVNVAVGA
DDTITTPAACERLALAAGTPLQVVPRAGHAGYIEAPAAYTAIIDTFCRASDGQRSQ

Download         Length: 891 bp

>T89307 NZ_CP024942:c1100494-1099604 [Paraburkholderia terricola]
ATGTCCGCAGTCCCGTCCGCTACCGCCGATCAGAACGCCACGCTCGAAGCGCGTCTTGCGCGCTTTCCCGCGCAGCAGAT
CTGGCTTGCATCGCAACGCGCGGTGAGCTATCGCGAAGCGAACAGCGCCGCAACGAACGCGCTGCCGCTCGTGTTGCTGC
ACGGTATCGGTTCGGGCGCGGCTTCGTGGGTGCAGCAATTCGAAACGCTCGGCGACACGCGCCGCGTGATTGCGTGGGAT
GCGCCGGGTTATGGCGCCTCCACGCCGGTCACGCCTGAATCGCCCGCGGCGGCAGATTACGCCGCGGTATTGAACGAATG
GCTCGACGCGCTCGCCATCGAACGTTGTGTGCTGCTCGGCCATTCACTCGGCGCGATCATCGCGGGTGCGTTCGCCATGA
CGTATCCGCGGCGTGTGGCCGGTTTGCTGTTGCTGTCGCCGGCGGGCGGTTATGGCGCGGCATCCGCGGCGGTACGCGAG
ACGAAGCGCGCTCAACGCCTCGCGATGCTCGAGGCGTTGGGCCCGCAAGGACTCGCCGAAAAACGCAGCGCCGCTATGTT
GTCCGCTTACGCGAGCGACGAAGCGCGCGCGTGGGTGCGCTGGAACATGTCGCGCGTGATTCCGCATGGCTACGCCCAGG
CGACCCATCTGCTCGCCAACGCCGACCTCGCCGCCGACCTCGTGCGTTACAGCGGCCGCGTCAACGTGGCCGTCGGCGCC
GACGACACCATTACGACGCCCGCAGCCTGCGAACGACTCGCACTGGCGGCGGGCACCCCATTGCAAGTCGTGCCACGCGC
GGGGCACGCCGGCTATATCGAAGCACCCGCCGCGTACACCGCGATCATCGACACGTTCTGCCGCGCGAGCGACGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 284 a.a.        Molecular weight: 31349.81 Da        Isoelectric Point: 9.5560

>AT89307 WP_083083022.1 NZ_CP024942:c1099546-1098695 [Paraburkholderia terricola]
IGNDSDTNNDTGYRVPGLERGLRILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLERADKDRNYRLGVAVL
RLGFEYLSSLELTDLGLPIIEALRDETGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAHATTHGQVLMGDM
TLDELKKLYPEPELERFTKQTPVTVDDLYERIRDDARRGFAISESSFERGISVVSAPVRNDTGRIVAVITTTIPRHEIGA
SLLDSGLIDKVRRAAGELSQRLNHRPKSGPDAGSKYMKALGLR

Download         Length: 852 bp

>AT89307 NZ_CP024942:c1099546-1098695 [Paraburkholderia terricola]
ATCGGCAACGACAGCGATACCAACAATGACACCGGCTATCGCGTGCCCGGTCTCGAACGCGGCCTGAGGATTCTCACGGA
GTTTTCGCCGCGCGAGCCGGTTCTCGGCGCACCGGAACTATCGAAGCGCCTGAAGATTCCTCGCACGACGGTGTTCCGTC
TGCTGCAAACACTCGAATCGCTCGGCTTTCTCGAACGCGCCGATAAGGACCGCAACTATCGCCTCGGCGTCGCGGTGCTG
CGGCTCGGTTTCGAATATCTGAGCTCGCTCGAATTGACCGACCTCGGCCTGCCGATCATCGAAGCCTTGCGCGACGAAAC
CGGCTTGACCAGCCATATCGTGATTCGCGATGGACGCGACGTCGTGTTCGTCGCCAAGGCGCAAAGCCACGCGCCGATTT
TCAGTTCGGTGAAGGTCAACGTCGGCACCCGTTTGCCGGCTCACGCCACGACGCATGGTCAGGTGCTGATGGGCGACATG
ACGCTCGACGAGTTGAAGAAGCTCTATCCCGAGCCCGAACTCGAACGCTTCACCAAACAGACGCCCGTCACCGTCGACGA
TTTATACGAGCGCATTCGCGACGACGCACGGCGCGGTTTCGCGATCAGCGAGTCGTCGTTCGAGCGCGGCATTTCAGTGG
TCAGCGCGCCGGTGCGCAACGACACGGGCCGCATCGTCGCCGTGATCACGACAACGATTCCGCGCCACGAGATCGGCGCG
TCGCTGCTCGACAGCGGGTTGATCGACAAGGTCCGCCGCGCCGCCGGCGAACTCTCGCAGCGGCTCAATCACCGGCCCAA
GAGCGGGCCGGATGCGGGCAGCAAATACATGAAGGCATTGGGGCTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References