Detailed information of TA system TA089301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1124184..1124851
• Replicon: chromosome
• Accession: NZ_CP024941
• Organism: Paraburkholderia terricola strain mHS1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CUJ90_RS04990
• Protein ID: WP_073429536.1
• Coordinates: 1124184..1124360 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CUJ90_RS04995
• Protein ID: WP_114162125.1
• Coordinates: 1124429..1124851 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUJ90_RS04970	1119349..1120110	-	762	WP_073429591.1	nicotinate-nucleotide adenylyltransferase	-
CUJ90_RS04975	1120163..1121086	-	924	WP_073429533.1	oxygen-dependent coproporphyrinogen oxidase	-
CUJ90_RS04980	1121341..1122639	-	1299	WP_073429534.1	phosphoribosylamine--glycine ligase	-
CUJ90_RS04985	1122896..1123624	-	729	WP_083085213.1	YebC/PmpR family DNA-binding transcriptional regulator	-
CUJ90_RS04990	1124184..1124360	+	177	WP_073429536.1	type II toxin-antitoxin system HicA family toxin	Toxin
CUJ90_RS04995	1124429..1124851	+	423	WP_114162125.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CUJ90_RS05000	1124915..1125565	-	651	WP_073429538.1	uracil phosphoribosyltransferase	-
CUJ90_RS05005	1125804..1126583	+	780	WP_114162126.1	SDR family oxidoreductase	-
CUJ90_RS05010	1126671..1127060	+	390	WP_114162127.1	methylglyoxal synthase	-
CUJ90_RS05015	1127121..1128095	+	975	WP_114163442.1	quinone oxidoreductase	-
CUJ90_RS05025	1128370..1128462	+	93	WP_073429542.1	K(+)-transporting ATPase subunit F	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-55)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-65)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6767.83 Da
• Isoelectric Point: 11.0745

>T89301 WP_073429536.1 NZ_CP024941:1124184-1124360 [Paraburkholderia terricola]
VKQSEFRRWLADQGATFQQGSKHLKVYLNGRQTTLPRHPAHEISEPLRQAILKQLKCK

Nucleotide

• Length: 177 bp

>T89301 NZ_CP024941:1124184-1124360 [Paraburkholderia terricola]
GTGAAGCAAAGCGAGTTCAGACGTTGGCTCGCTGACCAGGGAGCGACTTTCCAGCAAGGCAGCAAGCATTTGAAGGTGTA
TCTGAACGGTCGGCAGACCACGCTGCCGAGGCATCCCGCTCATGAGATCTCGGAGCCGCTTCGTCAAGCAATTCTCAAAC
AACTGAAATGCAAATAG

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15311.72 Da
• Isoelectric Point: 5.7918

>AT89301 WP_114162125.1 NZ_CP024941:1124429-1124851 [Paraburkholderia terricola]
MFRYPARIEPDEGGFTVSFRDIPEALTSGGTLEEAREMAADALATAMDFYFEDKRPVPLPSKVRRGETLIELPASLAAKV
LLLNEMLAQKVSPAELARRLHTRSQDIQRVIDLGHATKIDTIAAALAALGKRLELSIVPA

Nucleotide

• Length: 423 bp

>AT89301 NZ_CP024941:1124429-1124851 [Paraburkholderia terricola]
ATGTTTCGCTATCCCGCACGCATCGAACCGGATGAAGGCGGTTTTACCGTGTCCTTTCGTGACATTCCCGAGGCGCTGAC
CAGCGGCGGCACACTCGAGGAAGCGCGTGAAATGGCGGCCGACGCGCTGGCGACCGCGATGGATTTCTACTTCGAAGACA
AGCGCCCGGTGCCGTTGCCGTCAAAGGTGCGGCGCGGCGAAACGCTGATCGAATTGCCTGCCAGCCTGGCCGCAAAGGTG
CTGCTGCTCAACGAGATGCTGGCGCAAAAAGTGTCGCCTGCCGAACTCGCCAGGCGCCTTCACACGCGTTCGCAGGACAT
CCAGCGTGTGATCGACCTCGGTCACGCGACCAAGATCGACACGATCGCGGCGGCGCTCGCCGCACTGGGAAAGCGACTCG
AGTTGTCGATCGTTCCGGCCTGA