Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ParST/RES-TIGR02293 |
| Location | 880997..882009 | Replicon | plasmid pmHSR1_P |
| Accession | NZ_CP024940 | ||
| Organism | Paraburkholderia hospita strain mHSR1 | ||
Toxin (Protein)
| Gene name | ParT | Uniprot ID | - |
| Locus tag | CUJ88_RS48125 | Protein ID | WP_114224664.1 |
| Coordinates | 881533..882009 (+) | Length | 159 a.a. |
Antitoxin (Protein)
| Gene name | ParS | Uniprot ID | - |
| Locus tag | CUJ88_RS48120 | Protein ID | WP_114224923.1 |
| Coordinates | 880997..881536 (+) | Length | 180 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CUJ88_RS48090 | 876133..876446 | + | 314 | Protein_854 | single-stranded DNA-binding protein | - |
| CUJ88_RS48095 | 876565..877044 | - | 480 | WP_090837067.1 | hypothetical protein | - |
| CUJ88_RS48100 | 877394..877783 | - | 390 | WP_090837064.1 | type II toxin-antitoxin system VapC family toxin | - |
| CUJ88_RS48105 | 877780..878049 | - | 270 | WP_007741389.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| CUJ88_RS48110 | 878517..878798 | + | 282 | WP_114224921.1 | hypothetical protein | - |
| CUJ88_RS48115 | 878815..880332 | - | 1518 | WP_114224922.1 | sensor domain-containing diguanylate cyclase | - |
| CUJ88_RS48120 | 880997..881536 | + | 540 | WP_114224923.1 | DUF2384 domain-containing protein | Antitoxin |
| CUJ88_RS48125 | 881533..882009 | + | 477 | WP_114224664.1 | RES family NAD+ phosphorylase | Toxin |
| CUJ88_RS48135 | 882857..883138 | + | 282 | WP_007585013.1 | DUF3303 family protein | - |
| CUJ88_RS48140 | 883219..883539 | + | 321 | WP_086917608.1 | antibiotic biosynthesis monooxygenase | - |
| CUJ88_RS48145 | 883661..885436 | + | 1776 | WP_007585011.1 | alkaline phosphatase D family protein | - |
| CUJ88_RS48150 | 885545..886153 | + | 609 | WP_007585009.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..1235162 | 1235162 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 159 a.a. Molecular weight: 17035.61 Da Isoelectric Point: 7.7440
>T89300 WP_114224664.1 NZ_CP024940:881533-882009 [Paraburkholderia hospita]
VTVAVWRIATEAPNYPADDLSGAGAKATGGRWNRRGTPVLYCASTIALACLETVVHIRAAGLPLNRYLVCLDVPDNVWQA
ATVFTNISAPIGWDAIPPGMTSLDTGEKWIYKAATALLLVPSVIVPEETNVLINPAHPDAAGIRAQKVRRWTYDQRMG
VTVAVWRIATEAPNYPADDLSGAGAKATGGRWNRRGTPVLYCASTIALACLETVVHIRAAGLPLNRYLVCLDVPDNVWQA
ATVFTNISAPIGWDAIPPGMTSLDTGEKWIYKAATALLLVPSVIVPEETNVLINPAHPDAAGIRAQKVRRWTYDQRMG
Download Length: 477 bp
>T89300 NZ_CP024940:881533-882009 [Paraburkholderia hospita]
GTGACAGTCGCGGTCTGGCGGATCGCGACCGAAGCGCCCAACTACCCCGCAGACGATCTTTCAGGTGCCGGCGCGAAGGC
GACGGGTGGCCGGTGGAACCGGCGCGGAACGCCGGTTTTGTACTGTGCGTCGACCATCGCCCTGGCCTGTCTGGAAACCG
TGGTTCACATTCGCGCGGCGGGATTGCCGCTGAACCGCTACCTCGTGTGTCTGGACGTGCCCGACAACGTCTGGCAGGCC
GCGACGGTTTTCACGAACATCTCAGCGCCCATAGGATGGGACGCAATCCCGCCCGGTATGACGAGCCTGGATACAGGTGA
GAAATGGATCTATAAGGCTGCCACAGCCCTGCTTCTTGTGCCGTCTGTCATCGTCCCGGAGGAGACGAACGTCCTCATCA
ACCCGGCCCATCCGGATGCCGCGGGCATTCGTGCGCAGAAAGTGCGGCGTTGGACCTACGATCAGCGAATGGGTTAA
GTGACAGTCGCGGTCTGGCGGATCGCGACCGAAGCGCCCAACTACCCCGCAGACGATCTTTCAGGTGCCGGCGCGAAGGC
GACGGGTGGCCGGTGGAACCGGCGCGGAACGCCGGTTTTGTACTGTGCGTCGACCATCGCCCTGGCCTGTCTGGAAACCG
TGGTTCACATTCGCGCGGCGGGATTGCCGCTGAACCGCTACCTCGTGTGTCTGGACGTGCCCGACAACGTCTGGCAGGCC
GCGACGGTTTTCACGAACATCTCAGCGCCCATAGGATGGGACGCAATCCCGCCCGGTATGACGAGCCTGGATACAGGTGA
GAAATGGATCTATAAGGCTGCCACAGCCCTGCTTCTTGTGCCGTCTGTCATCGTCCCGGAGGAGACGAACGTCCTCATCA
ACCCGGCCCATCCGGATGCCGCGGGCATTCGTGCGCAGAAAGTGCGGCGTTGGACCTACGATCAGCGAATGGGTTAA
Antitoxin
Download Length: 180 a.a. Molecular weight: 19426.21 Da Isoelectric Point: 10.1681
>AT89300 WP_114224923.1 NZ_CP024940:880997-881536 [Paraburkholderia hospita]
VNAPATSARRPPARKTAVRVPAKPAAPSRAAKAHATKINDYLTLYHAPPLERISFIKYGVDAYDVYVLARNMGTSQDNLM
VTLGLPRSTIIRKAKGKARLSAEQSERVIGMARLVGQVEAMVAESGNPEGFDAAHWVNEWLDQPNPALDQRRPAEFMDTV
AGQEFVASLLAKAQSGAYV
VNAPATSARRPPARKTAVRVPAKPAAPSRAAKAHATKINDYLTLYHAPPLERISFIKYGVDAYDVYVLARNMGTSQDNLM
VTLGLPRSTIIRKAKGKARLSAEQSERVIGMARLVGQVEAMVAESGNPEGFDAAHWVNEWLDQPNPALDQRRPAEFMDTV
AGQEFVASLLAKAQSGAYV
Download Length: 540 bp
>AT89300 NZ_CP024940:880997-881536 [Paraburkholderia hospita]
GTGAACGCGCCTGCCACCTCCGCCCGTCGCCCGCCGGCCCGCAAGACTGCAGTTCGTGTCCCGGCAAAACCCGCCGCGCC
GTCGCGGGCTGCCAAAGCGCACGCGACGAAGATCAACGATTACCTCACCCTCTATCACGCGCCTCCGCTCGAGCGCATCA
GCTTCATCAAGTACGGCGTGGATGCCTACGACGTGTACGTTCTTGCGCGCAACATGGGAACCTCGCAGGACAACCTGATG
GTGACCTTGGGGCTGCCGCGCTCGACCATCATCCGTAAGGCCAAGGGGAAGGCGCGTCTGTCCGCGGAGCAGAGCGAACG
GGTGATCGGTATGGCGAGGCTGGTCGGCCAGGTCGAAGCGATGGTCGCCGAATCCGGGAATCCGGAAGGCTTCGACGCCG
CCCACTGGGTAAACGAATGGCTGGACCAGCCCAACCCGGCACTGGATCAGCGCCGTCCTGCTGAGTTCATGGATACGGTC
GCGGGACAGGAATTTGTCGCTTCCCTGCTGGCGAAGGCACAGAGCGGAGCGTACGTGTGA
GTGAACGCGCCTGCCACCTCCGCCCGTCGCCCGCCGGCCCGCAAGACTGCAGTTCGTGTCCCGGCAAAACCCGCCGCGCC
GTCGCGGGCTGCCAAAGCGCACGCGACGAAGATCAACGATTACCTCACCCTCTATCACGCGCCTCCGCTCGAGCGCATCA
GCTTCATCAAGTACGGCGTGGATGCCTACGACGTGTACGTTCTTGCGCGCAACATGGGAACCTCGCAGGACAACCTGATG
GTGACCTTGGGGCTGCCGCGCTCGACCATCATCCGTAAGGCCAAGGGGAAGGCGCGTCTGTCCGCGGAGCAGAGCGAACG
GGTGATCGGTATGGCGAGGCTGGTCGGCCAGGTCGAAGCGATGGTCGCCGAATCCGGGAATCCGGAAGGCTTCGACGCCG
CCCACTGGGTAAACGAATGGCTGGACCAGCCCAACCCGGCACTGGATCAGCGCCGTCCTGCTGAGTTCATGGATACGGTC
GCGGGACAGGAATTTGTCGCTTCCCTGCTGGCGAAGGCACAGAGCGGAGCGTACGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|