Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParST/RES-TIGR02293
Location 880997..882009 Replicon plasmid pmHSR1_P
Accession NZ_CP024940
Organism Paraburkholderia hospita strain mHSR1

Toxin (Protein)


Gene name ParT Uniprot ID -
Locus tag CUJ88_RS48125 Protein ID WP_114224664.1
Coordinates 881533..882009 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name ParS Uniprot ID -
Locus tag CUJ88_RS48120 Protein ID WP_114224923.1
Coordinates 880997..881536 (+) Length 180 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ88_RS48090 876133..876446 + 314 Protein_854 single-stranded DNA-binding protein -
CUJ88_RS48095 876565..877044 - 480 WP_090837067.1 hypothetical protein -
CUJ88_RS48100 877394..877783 - 390 WP_090837064.1 type II toxin-antitoxin system VapC family toxin -
CUJ88_RS48105 877780..878049 - 270 WP_007741389.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
CUJ88_RS48110 878517..878798 + 282 WP_114224921.1 hypothetical protein -
CUJ88_RS48115 878815..880332 - 1518 WP_114224922.1 sensor domain-containing diguanylate cyclase -
CUJ88_RS48120 880997..881536 + 540 WP_114224923.1 DUF2384 domain-containing protein Antitoxin
CUJ88_RS48125 881533..882009 + 477 WP_114224664.1 RES family NAD+ phosphorylase Toxin
CUJ88_RS48135 882857..883138 + 282 WP_007585013.1 DUF3303 family protein -
CUJ88_RS48140 883219..883539 + 321 WP_086917608.1 antibiotic biosynthesis monooxygenase -
CUJ88_RS48145 883661..885436 + 1776 WP_007585011.1 alkaline phosphatase D family protein -
CUJ88_RS48150 885545..886153 + 609 WP_007585009.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1235162 1235162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(5-153)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(68-113)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 17035.61 Da        Isoelectric Point: 7.7440

>T89300 WP_114224664.1 NZ_CP024940:881533-882009 [Paraburkholderia hospita]
VTVAVWRIATEAPNYPADDLSGAGAKATGGRWNRRGTPVLYCASTIALACLETVVHIRAAGLPLNRYLVCLDVPDNVWQA
ATVFTNISAPIGWDAIPPGMTSLDTGEKWIYKAATALLLVPSVIVPEETNVLINPAHPDAAGIRAQKVRRWTYDQRMG

Download         Length: 477 bp

>T89300 NZ_CP024940:881533-882009 [Paraburkholderia hospita]
GTGACAGTCGCGGTCTGGCGGATCGCGACCGAAGCGCCCAACTACCCCGCAGACGATCTTTCAGGTGCCGGCGCGAAGGC
GACGGGTGGCCGGTGGAACCGGCGCGGAACGCCGGTTTTGTACTGTGCGTCGACCATCGCCCTGGCCTGTCTGGAAACCG
TGGTTCACATTCGCGCGGCGGGATTGCCGCTGAACCGCTACCTCGTGTGTCTGGACGTGCCCGACAACGTCTGGCAGGCC
GCGACGGTTTTCACGAACATCTCAGCGCCCATAGGATGGGACGCAATCCCGCCCGGTATGACGAGCCTGGATACAGGTGA
GAAATGGATCTATAAGGCTGCCACAGCCCTGCTTCTTGTGCCGTCTGTCATCGTCCCGGAGGAGACGAACGTCCTCATCA
ACCCGGCCCATCCGGATGCCGCGGGCATTCGTGCGCAGAAAGTGCGGCGTTGGACCTACGATCAGCGAATGGGTTAA

Antitoxin


Download         Length: 180 a.a.        Molecular weight: 19426.21 Da        Isoelectric Point: 10.1681

>AT89300 WP_114224923.1 NZ_CP024940:880997-881536 [Paraburkholderia hospita]
VNAPATSARRPPARKTAVRVPAKPAAPSRAAKAHATKINDYLTLYHAPPLERISFIKYGVDAYDVYVLARNMGTSQDNLM
VTLGLPRSTIIRKAKGKARLSAEQSERVIGMARLVGQVEAMVAESGNPEGFDAAHWVNEWLDQPNPALDQRRPAEFMDTV
AGQEFVASLLAKAQSGAYV

Download         Length: 540 bp

>AT89300 NZ_CP024940:880997-881536 [Paraburkholderia hospita]
GTGAACGCGCCTGCCACCTCCGCCCGTCGCCCGCCGGCCCGCAAGACTGCAGTTCGTGTCCCGGCAAAACCCGCCGCGCC
GTCGCGGGCTGCCAAAGCGCACGCGACGAAGATCAACGATTACCTCACCCTCTATCACGCGCCTCCGCTCGAGCGCATCA
GCTTCATCAAGTACGGCGTGGATGCCTACGACGTGTACGTTCTTGCGCGCAACATGGGAACCTCGCAGGACAACCTGATG
GTGACCTTGGGGCTGCCGCGCTCGACCATCATCCGTAAGGCCAAGGGGAAGGCGCGTCTGTCCGCGGAGCAGAGCGAACG
GGTGATCGGTATGGCGAGGCTGGTCGGCCAGGTCGAAGCGATGGTCGCCGAATCCGGGAATCCGGAAGGCTTCGACGCCG
CCCACTGGGTAAACGAATGGCTGGACCAGCCCAACCCGGCACTGGATCAGCGCCGTCCTGCTGAGTTCATGGATACGGTC
GCGGGACAGGAATTTGTCGCTTCCCTGCTGGCGAAGGCACAGAGCGGAGCGTACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References