Detailed information of TA system TA089299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 376204..376742
• Replicon: plasmid pmHSR1_P
• Accession: NZ_CP024940
• Organism: Paraburkholderia hospita strain mHSR1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CUJ88_RS45505
• Protein ID: WP_114224366.1
• Coordinates: 376443..376742 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A7Z7BL02
• Locus tag: CUJ88_RS45500
• Protein ID: WP_007738653.1
• Coordinates: 376204..376446 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUJ88_RS45470	371948..372655	+	708	WP_086915042.1	StbB	-
CUJ88_RS45475	372655..373107	+	453	WP_086915041.1	hypothetical protein	-
CUJ88_RS45480	373118..373450	+	333	WP_009771254.1	Killer protein	-
CUJ88_RS45490	374466..375707	+	1242	Protein_360	cystathionine gamma-synthase family protein	-
CUJ88_RS45495	375742..376092	+	351	WP_114224365.1	hypothetical protein	-
CUJ88_RS45500	376204..376446	+	243	WP_007738653.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CUJ88_RS45505	376443..376742	+	300	WP_114224366.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CUJ88_RS45510	378927..380918	+	1992	WP_114224367.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..1235162	1235162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11322.83 Da
• Isoelectric Point: 5.4865

>T89299 WP_114224366.1 NZ_CP024940:376443-376742 [Paraburkholderia hospita]
VKEIVLSPAAELDLDDIWDYSAENWGIRQAERYIRMIQDTIVGLTDGTQPSQAVSHVRPGYRSVLVGTHILFFKETANLI
DVIRILHQRMDPSQHLSEH

Nucleotide

• Length: 300 bp

>T89299 NZ_CP024940:376443-376742 [Paraburkholderia hospita]
GTGAAGGAAATTGTTCTCTCGCCAGCGGCCGAGCTGGATCTCGATGATATCTGGGACTATTCGGCGGAAAACTGGGGGAT
ACGGCAGGCGGAGCGTTATATCCGCATGATCCAGGACACGATCGTTGGATTGACTGATGGTACACAGCCGAGTCAGGCCG
TCTCCCACGTTCGGCCTGGCTACCGCAGTGTGCTGGTCGGAACTCACATTCTGTTTTTCAAAGAGACCGCCAACCTTATC
GACGTTATCCGGATTCTTCATCAGCGGATGGATCCTTCCCAACACCTGAGCGAGCACTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8970.06 Da
• Isoelectric Point: 8.6582

>AT89299 WP_007738653.1 NZ_CP024940:376204-376446 [Paraburkholderia hospita]
MGKNTSVSLGDHFAEFVEDRVRAGRYNTASDVVRAGLRLLEEQEAKLDALRVELEKGERSGPSRPFDFDAFLARKRKSAT

Nucleotide

• Length: 243 bp

>AT89299 NZ_CP024940:376204-376446 [Paraburkholderia hospita]
ATGGGCAAGAACACATCCGTTTCGCTCGGCGACCACTTCGCCGAATTTGTCGAAGATCGCGTGCGCGCCGGGCGCTACAA
CACGGCGAGCGACGTGGTTCGAGCTGGCCTGCGTTTGCTAGAGGAACAGGAAGCAAAACTCGATGCCCTGCGCGTCGAGC
TGGAGAAGGGCGAGCGCTCGGGCCCATCCAGGCCATTTGACTTCGACGCGTTTCTCGCACGCAAGAGGAAGTCCGCGACG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7BL02