Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1299158..1299783 Replicon chromosome
Accession NZ_CP024938
Organism Paraburkholderia hospita strain mHSR1

Toxin (Protein)


Gene name mazF Uniprot ID A0A244DM89
Locus tag CUJ88_RS23580 Protein ID WP_007583020.1
Coordinates 1299439..1299783 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A244DMF0
Locus tag CUJ88_RS23575 Protein ID WP_007583018.1
Coordinates 1299158..1299430 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ88_RS23550 1295614..1296774 + 1161 WP_079500597.1 DUF1501 domain-containing protein -
CUJ88_RS23555 1296850..1297074 + 225 WP_039900693.1 YXWGXW repeat-containing protein -
CUJ88_RS23560 1297213..1297698 + 486 WP_007583012.1 VOC family protein -
CUJ88_RS23565 1297792..1298268 + 477 WP_114222851.1 VOC family protein -
CUJ88_RS23570 1298376..1298900 + 525 WP_039900694.1 GNAT family N-acetyltransferase -
CUJ88_RS23575 1299158..1299430 + 273 WP_007583018.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CUJ88_RS23580 1299439..1299783 + 345 WP_007583020.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CUJ88_RS23585 1299797..1300516 - 720 WP_007583022.1 GNAT family N-acetyltransferase -
CUJ88_RS23590 1300734..1301948 + 1215 WP_114222120.1 DUF2252 domain-containing protein -
CUJ88_RS23595 1302197..1302523 + 327 WP_007583025.1 hypothetical protein -
CUJ88_RS23600 1302704..1303288 + 585 WP_007583028.1 flavin reductase family protein -
CUJ88_RS23605 1303314..1304159 - 846 WP_114222121.1 AraC family transcriptional regulator -
CUJ88_RS23610 1304250..1304609 - 360 WP_086916912.1 nuclear transport factor 2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-111)

Antitoxin

Antitoxin PemI-like

(5-80)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12742.76 Da        Isoelectric Point: 7.3242

>T89298 WP_007583020.1 NZ_CP024938:1299439-1299783 [Paraburkholderia hospita]
MKNGVPEIGDVWWMSLEPVVGHEQGGSYPRPVVVLSHHEHNGPAQRIVAVPCTSKIRGFSTEIPVSALSKPCVALIDQIT
TLDWVARRGEFREERIAQPELDAIRRSLKAFLMM

Download         Length: 345 bp

>T89298 NZ_CP024938:1299439-1299783 [Paraburkholderia hospita]
ATGAAGAACGGCGTTCCCGAAATCGGCGATGTGTGGTGGATGAGTCTCGAACCCGTGGTCGGGCACGAGCAGGGCGGCAG
TTATCCTCGGCCCGTGGTGGTGTTGTCGCACCACGAGCACAACGGTCCGGCACAGCGCATTGTCGCCGTGCCGTGCACGT
CGAAGATACGCGGTTTTTCGACGGAGATTCCCGTCTCCGCGTTGTCAAAGCCGTGCGTCGCGCTGATCGACCAGATCACC
ACGCTCGACTGGGTGGCGCGGCGCGGTGAATTCAGGGAAGAGCGGATCGCGCAGCCCGAACTGGATGCGATCCGCCGCAG
TTTGAAAGCATTCCTGATGATGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9963.06 Da        Isoelectric Point: 4.1606

>AT89298 WP_007583018.1 NZ_CP024938:1299158-1299430 [Paraburkholderia hospita]
MAIQTIKRWGNSLAVRIPASLAEELHLREDQEVDMVVADGALVATPAIRTFNWDEYREQLAARPGDVHPTIDHGVAVGSE
LADPTDQDDW

Download         Length: 273 bp

>AT89298 NZ_CP024938:1299158-1299430 [Paraburkholderia hospita]
ATGGCTATTCAGACAATCAAGCGGTGGGGCAACAGTCTTGCGGTGCGCATTCCCGCAAGCCTGGCGGAGGAACTGCACCT
GCGCGAAGATCAGGAAGTCGACATGGTGGTAGCGGATGGAGCGCTCGTCGCAACGCCCGCCATCAGGACGTTCAATTGGG
ACGAGTATCGCGAGCAACTGGCGGCGCGGCCCGGCGACGTGCATCCGACCATCGATCATGGCGTGGCTGTGGGTTCCGAA
CTTGCCGATCCAACGGACCAGGACGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244DM89

Antitoxin

Source ID Structure
AlphaFold DB A0A244DMF0

References