Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1134729..1136479 Replicon chromosome
Accession NZ_CP024938
Organism Paraburkholderia hospita strain mHSR1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CUJ88_RS22745 Protein ID WP_114222062.1
Coordinates 1135586..1136479 (-) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7Z7FI85
Locus tag CUJ88_RS22740 Protein ID WP_007587790.1
Coordinates 1134729..1135589 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ88_RS22720 1129925..1131421 - 1497 WP_114222059.1 aldehyde dehydrogenase -
CUJ88_RS22725 1131449..1132279 - 831 WP_114222060.1 aspartate dehydrogenase -
CUJ88_RS22730 1132272..1133930 - 1659 WP_114222061.1 thiamine pyrophosphate-binding protein -
CUJ88_RS22735 1133923..1134729 - 807 WP_007587788.1 SDR family oxidoreductase -
CUJ88_RS22740 1134729..1135589 - 861 WP_007587790.1 IclR family transcriptional regulator Antitoxin
CUJ88_RS22745 1135586..1136479 - 894 WP_114222062.1 alpha/beta fold hydrolase Toxin
CUJ88_RS22750 1136505..1137044 - 540 WP_086918329.1 cupin domain-containing protein -
CUJ88_RS22755 1137080..1137838 - 759 WP_079487637.1 SDR family oxidoreductase -
CUJ88_RS22760 1137831..1138919 - 1089 WP_086918328.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CUJ88_RS22765 1138974..1139285 - 312 WP_079487635.1 hypothetical protein -
CUJ88_RS22770 1139287..1139604 - 318 WP_007587796.1 non-heme iron oxygenase ferredoxin subunit -
CUJ88_RS22775 1140045..1141118 + 1074 WP_079500532.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-278)

Antitoxin

Transcription regulator IclR, N-terminal

(26-74)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 31265.23 Da        Isoelectric Point: 6.6553

>T89297 WP_114222062.1 NZ_CP024938:c1136479-1135586 [Paraburkholderia hospita]
MSAALPVTVCRNATLETRLSHFPAQQIAIAPQRTIGYREAGAAHADALPLVLLHGIGSGAASWVQQIETLGTTRRVFAWD
APGYGESTPVASASPESHEYAGALNAWLDALDVERCVLVGHSLGAIIAGSFAASHAERVAGLLLISPAAGYGAASEEVRA
SKRDSRLAMLSELGPQGLAEKRSANMLSPHADDASREWVRWNMSRIVPHGYAQATHLLANADLASDVAKINGRIAVAVGA
EDSITPPSSCERIAQAARTRLQIIPRAGHAGYIEAGTEYTALIDSFCRASDGQWSKA

Download         Length: 894 bp

>T89297 NZ_CP024938:c1136479-1135586 [Paraburkholderia hospita]
ATGTCCGCAGCCTTGCCCGTCACTGTCTGTCGAAACGCCACGCTGGAAACGCGCCTCTCGCACTTCCCGGCACAGCAGAT
CGCGATTGCGCCGCAACGCACGATCGGTTATCGCGAAGCGGGTGCCGCACATGCCGATGCGTTGCCGCTCGTGCTGTTGC
ACGGCATTGGCTCGGGCGCGGCTTCGTGGGTGCAACAGATCGAAACGCTCGGCACGACTCGCCGCGTGTTCGCGTGGGAC
GCGCCGGGCTACGGCGAATCGACACCTGTTGCGTCGGCTTCGCCGGAATCACATGAATATGCTGGCGCGCTCAACGCATG
GCTCGACGCGCTTGACGTAGAGCGTTGCGTACTGGTCGGGCATTCGCTCGGCGCGATCATCGCAGGCTCGTTCGCAGCGT
CGCATGCGGAACGCGTCGCGGGGCTGTTGCTGATTTCGCCCGCAGCGGGTTACGGCGCGGCATCCGAAGAAGTGCGCGCG
TCGAAGCGCGACAGCCGTCTCGCGATGCTCTCCGAACTCGGCCCGCAGGGACTCGCGGAAAAACGCAGCGCCAACATGCT
CTCGCCGCACGCGGACGACGCATCGCGCGAGTGGGTGCGCTGGAACATGTCGCGCATCGTGCCGCACGGTTACGCGCAAG
CGACGCATCTGCTCGCCAACGCGGACCTCGCCAGCGATGTCGCGAAGATCAACGGCCGTATCGCTGTCGCGGTCGGCGCG
GAAGACTCGATCACGCCGCCGTCGTCATGCGAGCGGATTGCGCAGGCGGCGCGCACGCGCCTGCAGATCATCCCGCGCGC
GGGTCACGCGGGCTATATCGAAGCGGGCACTGAATACACCGCGCTCATCGACTCATTCTGCCGCGCGAGCGACGGCCAAT
GGAGCAAAGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31480.89 Da        Isoelectric Point: 6.5092

>AT89297 WP_007587790.1 NZ_CP024938:c1135589-1134729 [Paraburkholderia hospita]
MTPELTGTAPEAEDDRNDANYRVPGLERGLRILTEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADRDRN
YRLGVAVLRLGFEYLSSLELTDLGLPLIEGLRDATGLTTHIVIRDGRDVVFVAKAQSHAPVFSSVKVNVGTRLPAHATTH
GHVLMGDLSLDELRALYPEKTLERFTKHTPATVDELYERVKDDAVRGFAISESSFENGISVISAPVRNDTGRIAAVITTT
IPRPQIDAALLDGGLIDKVRSAAEQLSLRLNYRPSAESRYMKALGL

Download         Length: 861 bp

>AT89297 NZ_CP024938:c1135589-1134729 [Paraburkholderia hospita]
ATGACCCCCGAATTGACGGGCACTGCGCCTGAAGCAGAAGACGACCGCAACGACGCGAACTATCGCGTGCCCGGACTCGA
ACGCGGCCTGCGCATTCTCACGGAGTTTTCGCCGCGCGAGCCGGTGCTCGGCGCGCCCGAGTTGTCGAAGCGCCTCGGCA
TTCCACGCACGACGGTGTTCCGGCTGTTGCAGACGCTCGAATCGCTCGGCTTTCTGGAGCGCGCGGATCGCGACCGCAAC
TATCGCCTGGGCGTCGCGGTGCTGCGCCTCGGCTTCGAATATCTCAGCTCGCTCGAACTCACCGATCTCGGCTTGCCGTT
GATCGAAGGTTTGCGCGACGCGACGGGGCTGACCACGCACATCGTGATCCGCGACGGCCGCGATGTGGTGTTCGTTGCGA
AGGCGCAGAGCCATGCGCCCGTGTTCAGCTCGGTGAAGGTGAACGTCGGCACGCGGTTGCCCGCGCATGCGACGACGCAC
GGTCATGTACTGATGGGTGATCTCTCGCTCGACGAACTGCGCGCGCTGTATCCGGAGAAGACGCTTGAACGCTTCACGAA
ACACACGCCCGCCACCGTCGACGAACTGTACGAGCGCGTGAAGGACGACGCGGTGCGCGGTTTCGCAATCAGCGAATCGT
CCTTTGAAAACGGCATTTCGGTGATCAGCGCGCCCGTGCGTAACGACACGGGCCGCATCGCCGCTGTCATCACGACGACG
ATTCCGCGTCCGCAGATCGACGCGGCGCTGCTTGATGGCGGCCTGATCGACAAGGTGCGTAGCGCGGCGGAGCAACTGTC
GCTGCGGCTGAACTATCGGCCGTCGGCGGAAAGCAGGTACATGAAGGCATTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7FI85

References