Detailed information of TA system TA089295

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-StbC
• Location: 1585773..1586433
• Replicon: chromosome
• Accession: NZ_CP024937
• Organism: Paraburkholderia hospita strain mHSR1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CUJ88_RS07100
• Protein ID: WP_079482156.1
• Coordinates: 1586005..1586433 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A7Z7B428
• Locus tag: CUJ88_RS07095
• Protein ID: WP_007588356.1
• Coordinates: 1585773..1586018 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CUJ88_RS07070	1581363..1581875	-	513	WP_007734063.1	Spy/CpxP family protein refolding chaperone	-
CUJ88_RS07075	1582028..1582912	+	885	WP_007588344.1	LysR family transcriptional regulator	-
CUJ88_RS07080	1583050..1583514	+	465	WP_007734062.1	Lrp/AsnC family transcriptional regulator	-
CUJ88_RS07085	1583722..1584819	+	1098	WP_114220794.1	saccharopine dehydrogenase NADP-binding domain-containing protein	-
CUJ88_RS07090	1584982..1585602	-	621	WP_114220795.1	ATP-binding protein	-
CUJ88_RS07095	1585773..1586018	+	246	WP_007588356.1	DNA-binding protein	Antitoxin
CUJ88_RS07100	1586005..1586433	+	429	WP_079482156.1	type II toxin-antitoxin system VapC family toxin	Toxin
CUJ88_RS07105	1586523..1586996	+	474	WP_114220796.1	hypothetical protein	-
CUJ88_RS07110	1587201..1588178	+	978	WP_114220797.1	magnesium/cobalt transporter CorA	-
CUJ88_RS07115	1588230..1588868	-	639	WP_007739112.1	LysE family translocator	-
CUJ88_RS07120	1589419..1590375	+	957	WP_007588361.1	sugar ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15778.96 Da
• Isoelectric Point: 6.8808

>T89295 WP_079482156.1 NZ_CP024937:1586005-1586433 [Paraburkholderia hospita]
VYLIDTNVISEMRKSSRANPGVQAFFETAKEGGHRLYLSVVTVGELRRGVDLIRHRGDKFQALRLEGWLDTIMNSFSSQI
LNVGTDVAQTWGHLRVPDPEHSLDKLIAATALIYNLTVVTRNVADFDGTGARVLNPFQLLDA

Nucleotide

• Length: 429 bp

>T89295 NZ_CP024937:1586005-1586433 [Paraburkholderia hospita]
GTGTATTTGATTGATACCAATGTAATCAGCGAAATGCGCAAGAGCAGCCGCGCCAATCCAGGCGTGCAGGCTTTTTTCGA
AACGGCGAAGGAAGGCGGGCATCGCCTGTATCTGTCGGTGGTGACGGTCGGCGAGCTGCGGCGCGGCGTCGACCTGATCC
GGCATCGGGGCGACAAGTTCCAGGCGTTGCGCCTGGAAGGCTGGCTCGACACGATCATGAATTCGTTCAGCAGCCAGATC
CTGAATGTCGGCACCGACGTCGCGCAGACGTGGGGCCATCTGCGCGTGCCGGATCCCGAGCACTCGCTGGACAAGCTGAT
CGCGGCGACGGCCCTGATCTACAACCTGACTGTCGTGACGCGCAACGTGGCAGACTTCGATGGCACGGGCGCACGGGTGC
TGAATCCGTTCCAGCTTCTTGACGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8938.94 Da
• Isoelectric Point: 4.2208

>AT89295 WP_007588356.1 NZ_CP024937:1585773-1586018 [Paraburkholderia hospita]
MANLLVRNLDDALVQNLREQAAAHGRSVEAEHREILAQALFQPKKLSFAELLMSMPDVGDDADFERRNDVTDDSGGPGVF
D

Nucleotide

• Length: 246 bp

>AT89295 NZ_CP024937:1585773-1586018 [Paraburkholderia hospita]
ATGGCAAATCTTTTGGTCCGAAATCTGGACGATGCGTTGGTGCAGAACCTGCGTGAGCAGGCCGCGGCTCACGGGCGCAG
CGTCGAAGCAGAGCATCGGGAAATCCTGGCGCAGGCGCTCTTTCAGCCCAAGAAGCTCAGCTTCGCGGAATTGCTGATGA
GCATGCCCGACGTCGGCGACGACGCCGACTTCGAGCGCCGCAATGACGTAACTGACGATAGCGGGGGACCGGGTGTATTT
GATTGA

Structures

Antitoxin

• AlphaFold DB: A0A7Z7B428