Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1264731..1265250 Replicon chromosome
Accession NZ_CP024937
Organism Paraburkholderia hospita strain mHSR1

Toxin (Protein)


Gene name relE Uniprot ID A0A244DDF8
Locus tag CUJ88_RS05625 Protein ID WP_007585572.1
Coordinates 1264960..1265250 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A244DDI0
Locus tag CUJ88_RS05620 Protein ID WP_007585570.1
Coordinates 1264731..1264973 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ88_RS05595 1259909..1260823 - 915 WP_007585563.1 ABC transporter permease -
CUJ88_RS05600 1260863..1261687 - 825 WP_079484863.1 ABC transporter permease -
CUJ88_RS05605 1261684..1262730 - 1047 WP_114220729.1 ABC transporter substrate-binding protein -
CUJ88_RS05610 1262774..1263847 - 1074 WP_007585568.1 LacI family DNA-binding transcriptional regulator -
CUJ88_RS05620 1264731..1264973 + 243 WP_007585570.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CUJ88_RS05625 1264960..1265250 + 291 WP_007585572.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CUJ88_RS05630 1265358..1265978 + 621 WP_114220730.1 glutathione S-transferase -
CUJ88_RS05640 1266196..1266387 + 192 WP_007585578.1 hypothetical protein -
CUJ88_RS05645 1266515..1267918 + 1404 WP_114220732.1 FAD-containing oxidoreductase -
CUJ88_RS05650 1267930..1268262 + 333 WP_086918625.1 cupin domain-containing protein -
CUJ88_RS05655 1268404..1268979 + 576 WP_007585583.1 DUF1211 domain-containing protein -
CUJ88_RS05660 1268983..1269771 + 789 WP_114220733.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10981.84 Da        Isoelectric Point: 10.5985

>T89294 WP_007585572.1 NZ_CP024937:1264960-1265250 [Paraburkholderia hospita]
MTIYKLQFLESAQKEWSKLDNTVRSQLKRKLAERLENPRVESARLSTMPDCYKIKLAASGYRLVYQVADRTVTVTVISVG
KRERSAVYAAAIARLM

Download         Length: 291 bp

>T89294 NZ_CP024937:1264960-1265250 [Paraburkholderia hospita]
TTGACGATCTATAAACTGCAGTTTCTTGAATCTGCCCAAAAGGAATGGAGCAAGCTCGATAACACGGTCCGTTCGCAGTT
AAAACGCAAGCTGGCCGAACGGCTGGAGAATCCGCGAGTCGAGTCGGCACGGCTGAGCACGATGCCAGACTGCTACAAAA
TCAAGCTTGCTGCATCGGGTTACAGACTGGTGTATCAGGTTGCGGACCGTACCGTGACGGTCACAGTGATTTCCGTTGGC
AAGCGCGAAAGAAGCGCAGTCTATGCTGCAGCAATTGCGCGTCTGATGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8657.90 Da        Isoelectric Point: 4.1954

>AT89294 WP_007585570.1 NZ_CP024937:1264731-1264973 [Paraburkholderia hospita]
MESILARTSIGISELKVNPTAAIEQADGPVAVLNRNKPVAYLIPAAEWEAICERLEDIELAEIVRARSGEKAVSVNLDDL

Download         Length: 243 bp

>AT89294 NZ_CP024937:1264731-1264973 [Paraburkholderia hospita]
ATGGAAAGCATTCTTGCGCGCACTTCGATCGGCATCAGCGAGCTCAAGGTCAACCCGACGGCAGCAATTGAGCAGGCAGA
CGGTCCGGTCGCGGTGTTGAATCGAAACAAGCCGGTCGCGTACCTGATCCCTGCGGCCGAATGGGAAGCGATTTGCGAGC
GACTCGAAGATATCGAGCTGGCGGAGATCGTCAGGGCGCGAAGCGGCGAGAAAGCCGTGAGCGTAAATCTTGACGATCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244DDF8

Antitoxin

Source ID Structure
AlphaFold DB A0A244DDI0

References