Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2616890..2618686 Replicon chromosome
Accession NZ_CP024935
Organism Paraburkholderia graminis strain PHS1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CUJ91_RS29880 Protein ID WP_114157841.1
Coordinates 2617784..2618686 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CUJ91_RS29875 Protein ID WP_114157840.1
Coordinates 2616890..2617783 (-) Length 298 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CUJ91_RS29855 2612068..2613558 - 1491 WP_114158105.1 aldehyde dehydrogenase -
CUJ91_RS29860 2613607..2614437 - 831 WP_006047372.1 aspartate dehydrogenase -
CUJ91_RS29865 2614430..2616088 - 1659 WP_044020272.1 thiamine pyrophosphate-binding protein -
CUJ91_RS29870 2616081..2616893 - 813 WP_114157839.1 SDR family oxidoreductase -
CUJ91_RS29875 2616890..2617783 - 894 WP_114157840.1 IclR family transcriptional regulator Antitoxin
CUJ91_RS29880 2617784..2618686 - 903 WP_114157841.1 alpha/beta hydrolase Toxin
CUJ91_RS29885 2618720..2619247 - 528 WP_053859783.1 cupin domain-containing protein -
CUJ91_RS29890 2619274..2620041 - 768 WP_114157842.1 SDR family oxidoreductase -
CUJ91_RS29895 2620034..2621113 - 1080 WP_114157843.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
CUJ91_RS29900 2621168..2621479 - 312 WP_006047380.1 hypothetical protein -
CUJ91_RS29905 2621481..2621795 - 315 WP_006047381.1 non-heme iron oxygenase ferredoxin subunit -
CUJ91_RS29910 2622226..2623299 + 1074 WP_006047382.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(49-278)

Antitoxin

Transcription regulator IclR, C-terminal

(150-274)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 31623.77 Da        Isoelectric Point: 7.2350

>T89292 WP_114157841.1 NZ_CP024935:c2618686-2617784 [Paraburkholderia graminis]
MSAVSSATAAASHATLEARVARFPARQVELASQRVLSYREACETSDALPLVLLHGIGSGAASWVQQFEALSASRRVLAWD
APGYGESTPVAAASPAATDYASLLYEWLEKLGIERCVLVGHSLGAIIAGSFAAMHPQRVAGLLLLSPAGGYGAASAEVRE
TKRDQRLAMLNELGPQGLAEKRSANMLSAHASDEARAWVRWNMSRVIPHGYAQATHLLANADLASDLARLKGRYNGRLHI
AVGADDTITTPAACERLALAADTQLQVVPHAGHAGYIEASAAYTAIIDTFCRASAGQRSQ

Download         Length: 903 bp

>T89292 NZ_CP024935:c2618686-2617784 [Paraburkholderia graminis]
ATGTCCGCAGTCTCGTCCGCTACCGCCGCAGCTTCACACGCCACGCTCGAAGCACGCGTTGCGCGCTTTCCTGCGCGGCA
GGTCGAACTGGCATCGCAGCGCGTGCTGAGTTATCGCGAAGCATGCGAGACGAGCGATGCGTTGCCGCTCGTGTTGCTGC
ACGGTATCGGCTCGGGCGCGGCTTCGTGGGTGCAGCAGTTCGAGGCATTGAGCGCGAGCCGTCGCGTGCTGGCGTGGGAC
GCGCCGGGTTATGGCGAATCGACGCCGGTTGCCGCCGCTTCTCCCGCAGCCACCGATTACGCAAGCCTGCTCTACGAATG
GCTGGAAAAGCTCGGCATCGAACGTTGCGTGCTGGTTGGTCATTCGCTCGGCGCGATCATCGCCGGTTCGTTTGCCGCGA
TGCATCCGCAGCGTGTGGCGGGTCTGTTGCTGTTGTCGCCGGCCGGCGGCTACGGCGCGGCTTCCGCGGAAGTGCGCGAG
ACGAAGCGCGATCAACGGCTCGCGATGCTCAACGAACTCGGCCCGCAAGGTCTCGCGGAAAAGCGCAGCGCCAATATGTT
GTCCGCGCATGCAAGCGACGAAGCGCGTGCATGGGTGCGCTGGAACATGTCGCGTGTGATTCCGCACGGCTACGCGCAGG
CCACGCATCTGCTCGCCAACGCGGACCTCGCCAGCGACCTCGCGCGTTTGAAGGGCCGCTATAACGGCCGCCTGCATATC
GCGGTCGGCGCGGACGACACCATTACGACTCCCGCGGCCTGCGAGCGACTCGCGCTCGCCGCGGATACCCAACTGCAAGT
CGTGCCACACGCGGGGCACGCCGGCTACATCGAAGCAAGCGCCGCGTACACCGCGATCATCGACACGTTCTGCCGCGCAA
GCGCCGGACAACGGAGCCAATGA

Antitoxin


Download         Length: 298 a.a.        Molecular weight: 33075.43 Da        Isoelectric Point: 5.8793

>AT89292 WP_114157840.1 NZ_CP024935:c2617783-2616890 [Paraburkholderia graminis]
MTPDTLNERDAEEDRNDSSDSNSDSSYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFLER
ADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRDETGLTAHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLP
AYATTHGQVLMGDMTLDELKKLYPEPELERFTRQTPATIDDLYERIRDDARRGFAISESSFERGISVVSAPVRNDTGRIV
AVITTTIPRQEIDASLLDSGLVDKVRRAADELSQRLNYRPGNGSNAGSKYMKALGLK

Download         Length: 894 bp

>AT89292 NZ_CP024935:c2617783-2616890 [Paraburkholderia graminis]
ATGACGCCCGACACCCTCAACGAGCGCGACGCGGAAGAAGACCGCAACGACAGCAGCGATAGCAACAGCGATAGCAGTTA
CCGCGTGCCCGGTCTGGAACGCGGTTTGAAGATCCTCACCGAATTCTCACCGCGCGAGCCGGTTCTCGGCGCGCCGGAAT
TGTCGCGACGCCTGAAGATTCCTCGCACGACAGTTTTCCGCTTGCTGCAAACGCTGGAATCGCTCGGCTTTCTCGAACGC
GCGGATAAAGACCGTAACTATCGACTCGGCGTCGCCGTGTTGCGCCTCGGCTTCGAATATCTGAGCTCGCTTGAATTGAC
CGACCTCGGCTTGCCGATCATCGAAGCCTTGCGCGACGAAACGGGTCTCACCGCGCACATTGTGATTCGCGATGGACGCG
ATGTCGTTTTCGTCGCAAAGGCGCAGAGCCACGCGCCGATTTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGCCTGCCC
GCATATGCAACGACGCACGGTCAGGTCCTGATGGGCGACATGACGCTGGACGAACTGAAAAAGCTTTATCCCGAGCCGGA
ACTTGAACGTTTCACCCGACAGACGCCCGCGACGATAGACGACCTCTACGAACGGATTCGCGACGACGCGCGGCGCGGTT
TCGCGATCAGCGAGTCGTCGTTCGAGCGCGGCATTTCGGTTGTCAGCGCGCCGGTGCGCAATGACACGGGGCGCATCGTC
GCCGTGATCACGACGACGATTCCGCGCCAGGAGATCGACGCGTCGCTGCTGGACAGCGGTCTGGTCGACAAAGTGCGCCG
CGCAGCCGACGAGCTTTCGCAGCGGCTCAATTACCGGCCGGGCAACGGTTCGAATGCGGGCAGCAAATACATGAAGGCAT
TGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References